Mini-Reviews in Organic Chemistry - Volume 18, Issue 1, 2021

Linoleic Acid (LA) (omega-6) and Alpha-Linolenic Acid (ALA) (omega-3) are essential fatty acids and give rise to Arachidonic Acid (AA), Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) that are important in metabolic homeostasis. The omega-6:omega-3 ratio can be a prognostic consideration in cardiovascular and inflammatory diseases. Sphingolipids are bioactive lipids found in cell membranes that pl Read More

Magnetic nanoparticles have gained a great deal of attention from both academic and industrial point of view, owing to their unique properties including high surface area, and superparamagnetism, which enable them to be suitable for modification with many compounds and employing them as a catalyst in organic reactions. In this mini-review, we have summarized the application of surface-modified magnetite nanopar Read More

The functionalization of the skeletal systems of heterocycles represents a significant goal for the development of new compounds. The heterocyclic molecule xanthine (3,7-dihydro-1Hpurine- 2,6-dione) is a purine base with a bicyclic ring skeleton and four different nitrogen atoms, three of them are -NH groups. The principal derivatives are the well known natural methylxanthines (e.g., caffeine, theophylline and theobromine) that Read More

There are four types of pyridopyrimidines namely pyrido[2,3-d], pyrido[3,4-d], pyrido[ 4,3-d]pyrimidines, and pyrido[3,2-d]pyrimidines. Different methods of preparation of pyrido[2,3- d]pyrimidines are summarized. Synthesis of pyrido[2,3-d]pyrimidines can be from pyrimidines derivatives or pyridine derivatives. We can start from pyrimidine derivatives and build a pyridine ring. 5,7-Diphenylpyrido[2,3-d]pyrimidines 3 and 4 we Read More

In this review article, we describe the application, reactivity and synthesis of isoxazole derivatives, more specifically, the application, reactivity, and synthesis of 3,5-disubstituted, 3,4- disubstituted, and 3,4,5-trisubstituted isoxazole using the green method. We review the application of isoxazole in material science, agriculture and pharmaceutical. In material science, isoxazole is used as a photochromic, electrochemical probe for Read More

Nowadays, carbon-based nanostructure materials are regarded as promising carriers for drug delivery to improve the effective treatment of diseases. The formation of covalent and noncovalent molecular bonds can be used for surface modification of nano-carriers in order to manipulate their toxicity, water solubility, and cellular internalization. Graphene and its derivatives have shown important potential in drug delivery s Read More

The heterocyclic compounds are the building blocks for the synthesis of the different biologically active compounds in the organic chemistry. Heterocyclic compounds have versatile synthetic applicability and biological activity. Pyrazole carboxylic acid derivatives are significant scaffold structures in heterocyclic compounds due to biologic activities such as antimicrobial, anticancer, inflammatory, antidepressant, antifung Read More

Thiophene derivatives are aromatic five-membered ring compounds made up of one sulfur as heteroatom. These compounds are present in a large number of natural and unnatural compounds with valuable bioactivities. Many of them have a wide range of applications in medicinal chemistry such as antimicrobial, anticancer, antiparasitic, anti-inflammatory, and antihypertensive activities. Some of them are famous Read More