Mini-Reviews in Organic Chemistry - Volume 18, Issue 6, 2021

Nucleosides and their analogues have been in use for many years and have become essential for treating patients with viral infections. Many additional nucleoside drugs have been approved over the past decades. This strongly demonstrates how important these compounds are and the crucial role they play. Given that a significant amount of research and literature has been documented regarding nucleoside analogues, Read More

Currently, there is a growing interest in the development of suitable methods for the preparation of eco-friendly and biocompatible materials in order to increase environmental protection and reduce human health risk. Therefore, this mini-review summarizes several studies involving lactides and lactones as monomers for the synthesis of biodegradable and biocompatible polymers via metal-catalyzed Ring-Opening Polymeriza Read More

This paper presents a short review of synthetic approaches aiming to synthesise (+)- Grandisol, the main constituent of grandlure, a pheromone mixture released by the boll weevil, which is proven to exhibit significant biological activity. (+)-Grandisol 1 is among the components of the male-produced pheromone of the boll weevil Anthonomuns grandis, an important pest of cotton crops in Mesoamerica (from the south USA t Read More

Tetrahydrocarbazoles (THC) is a privileged structural scaffold containing natural indole as the central moiety. This extraordinary skeleton features in a plethora of naturally occurring pharmacological compounds and alkaloids exhibiting a significant inhibitory activity such as antibacterial, protein kinase inhibitor, and tumor growth inhibitor, etc. Due to its versatile biological properties, it always gains considerable attention among t Read More

Gelatin produced from fish processing by-product is the most potential alternative source of gelatin. They have biological activities, particularly antioxidant, antihypertensive, and reduce type 2 diabetic risk. This paper reviews the mechanisms of fish gelatin hydrolysates for those human diseases being discussed in recent studies. Based on the review, mostly, skin and bone are used as sources of fish-based gelatin in whic Read More

In this review, we examine ‘greener’ routes to nanoparticles of iron oxides, in the recent years; nanotechnology has emerged as a state-of-the-art and cutting edge technology with multifarious applications in a wide array of fields. Natural products or extracted from natural products, such as different plant extracts, have been used as reductants and as capping agents during synthesis. A very easy, efficient, and environment-f Read More

New drugs introduced in the market each year, have privileged structures specifically for anticancer targets, of which quinoline-based analogues also play an important role. This review highlights quinoline and its derivatives, which have great potency against various cancer cells, including prostate cancer, breast cancer, colon cancer, pancreas cancer, and many more. This review describes the most preferred process-scal Read More

Benzoxazole compounds have an important and broad range of biological activities. The benzoxazole and its substituted derivatives possess antimicrobial, antitumor, anti-inflammatory, antihistaminic, anti-parasitic, herbicidal, anti-allergic, anti-helmintic, anti-tubercular, anticonvulsant, hypoglycaemic, HIV-1 reverse transcriptase inhibitor and insecticidal activities. It has also been shown to have a binding affinity to Aβ42 Read More

2-Imino-2H-chromene-3-carbo(thio)amides are considered versatile compounds because of their significance as building blocks in synthetic chemistry. In this review, we display all the available synthetic methods for 2-imino-2H-chromene-3-carbo(thio)amides as well as their reactions towards the different reagents. The presence of the imino and amide groups in these compounds makes C-4 the only reactive site of the Read More

The process of melanogenesis that takes place in the melanocytes of the epidermis, leads to hyperpigmentation. The biosynthetic pathway for the production of melanin involves the enzyme tyrosinase that has been an attractive target for cosmaceutical research. Numerous synthetic, semisynthetic and natural, especially plant-based, inhibitors of tyrosinase have been reported in the literature. In plants, the secondary Read More