Mini-Reviews in Organic Chemistry - Volume 12, Issue 6, 2015

Protein translational modification is an important regulating mechanism in the cellular activities and is also responsible for many human complex diseases, such as cancer. It is a foundation in the post-translational modification proteomics to accurately identify modified proteins or sites. A number of computational techniques have recently been developed to identify modified proteins or sites and greatly speed disclosure of Read More

Prediction of protein subcellular location is a meaningful task which attracts much attention in recent years. Particularly, the number of new protein sequences yielded by the high-throughput sequencing technology in the post genomic era has increased explosively. Facing such an avalanche of new protein sequences, it is both challenging and indispensable to develop an automated method for fast and accurately annotating the Read More

Protein folding, prediction of protein structure and functions are most important problems in bioinformatics. The protein fold process mainly reflects in the kinetic order of folding. Predicting the structural classes of low-homology protein is a difficult problem in the prediction of protein structure. In order to understanding the mechanism of programmed cell death, it is very necessary to obtain the information about subc Read More

Metabolic pathway analysis has become significant for evaluating intrinsic network characteristics in biochemical reaction network reconstruction. Current applications of metabolic pathway analysis involve identifying the enzyme for the desired production, identifying pathways of optimal production, determining non-redundant pathways for drug design, and genome comparisons by alignment of pathways for missing gene Read More

The comparison of DNA sequences is the basic topic in computational biology and bioinformatics, helping in speculation about their previously ambiguous structure, function, and evolution relationship. In this article, we provide a novel DNA sequence comparison scheme by constructing feature vectors based on Markov chain and information entropy. A new measure, which is calculated as the entropy of K-string’s four on Read More

A novel numerical characterization for graphical representations of DNA sequences is proposed, which consists of two steps: construction of a novel mathematical object that only takes the first row of the traditional mathematical object and then analysis of the similarities/dissimilarities using the distance between the objects of DNA sequences. Our novel mathematical object is only a row vector and calculation of the matrix invari Read More