Mini-Reviews in Organic Chemistry - Volume 12, Issue 1, 2015

Cu-catalyzed N-arylation of amides commonly known as Goldberg reaction is an important transformation in organic synthesis for the construction of pharmaceuticals and fine chemicals. This is the first review in this area which exclusively deals with recent developments in Goldberg reactions with special focus on mechanistic aspects, catalyst development as well as on the recent applications of this reaction in drug synthesis.

A novel series of coumarin fused benzothiazepines has been synthesized via coupling of oaminothiophenol with in situ generated 3-benzylidenechroman-2,4-diones. These novel compounds were screened for their in vitro antioxidant activity against free radical form of ABTS and cytotoxic activity against U87 human glioma cells. Molecular modeling and QSAR analysis were performed to explore comprehensive str Read More

Imidazole, an important azole heterocycle, having biological and medicinal properties prompted various research groups to develop different synthetic routes to this heterocycle. This review is an attempt to focus on the various synthetic routes involving conventional and new greener approaches for the synthesis of trisubstituted imidazoles.

The features of the chemistry of 4-thiazolidinone and isatin as privileged scaffolds were described in a number of reviews in which the main approaches to the synthesis of mentioned heterocycles and their pharmacological action were analyzed. However, the 4-thiazolidinone-indoline conjugates as well as isatin based heterocyclic hybrids as biologically active compounds is poorly discussed in the context of pharmacop Read More

2,5-Dihydroxyacetophenone (DHAP) is one of the three key chromophores found in aged cellulosics. Knowledge of the general reactivity and chemistry of this compound is helpful for a better understanding of cellulose aging and yellowing as well as bleaching of cellulosic materials - processes that also have considerable economic importance. This paper reviews the reactions reported for 2,5- dihydroxyacetophenone Read More

Among the family of nitrogen-containing heterocycles, quinoxalinone (or quinoxalin-2-one) core, characterized by pyrazin-2(1H)-one fused to benzene ring at two adjacent carbon atoms, has been frequently found in a variety of pharmacologically active compounds with biological or pharmaceutical applications. In this article, we highlighted the synthetic methods of this scaffold, as well as its derivates.