Mini-Reviews in Organic Chemistry - Volume 12, Issue 3, 2015

Proline chimeras are conformationally rigid amino acid analogues. Their application in medicinal chemistry for the synthesis of peptidomimetics is a well-known approach. Of particular interest are the natural Glu/Asp proline chimeras, namely Domoic acid and Kainic acid, for their toxic effect on the human health which have been used as probes for glutamatergic receptors studies. In this review, we analyze the most relevant syn Read More

α-Hydroxyphosphinates, displaying a wide range of activities from agriculture to medicine as fungicides or metalloenzyme inhibitors, are compounds of high interest. In particular, α- hydroxyalkylphosphinates, bis(α-hydroxyalkyl)phosphinates, optically active form of these compounds as well as their derivatives receive continuously growing synthetic attention. Their synthesis, although impressively old, has never been r Read More

The review offers an overview on the synthesis of phosphonated N,O-nucleosides, a new class of interesting, potential antiviral/ antitumor agents. The main synthetic method exploit a 1,3- dipolar cycloaddition reaction as key step. The cycloaddition process involves the use of phosphonated nitrones, or nitrones containing functional groups easily convertible into phosphonated group. Biological assays are presented, which sh Read More

A new methods for the synthesis of molecular pockets, molecular umbrellas as well as quasi podands of steroids derivatives have been described. Moreover, a molecular umbrellas and pockets derived from biogenic precursors and their applications are described. Intermolecular 1,3- dipolar cycloaddition gave a quasi podands with 1,2,3-triazole rings. The structures of the products were confirmed by spectral analysis, mass s Read More

Controlling the assembly of basic structural building blocks in a systematic and orderly fashion is an emerging issue in various areas of science and engineering such as physics, chemistry, material science, biological engineering, and electrical engineering. The self-assembly technique, among many other kinds of ordering techniques, has several unique advantages and the M13 bacteriophage can be utilized as part of this tech Read More

Sphingolipids are important cell membrane components among the phospholipid bilayer. Sphingolipid themselves and breakdown products play a significant role in signal transduction. All sphingolipids have a sphingosine backbone which is a long chain amino alcohol. Structurally, Sphingadienes differ from sphingosines due to the extra unsaturation present in the long aliphatic hydrocarbon chain. Sphingadienes have been isolate Read More

Glycochips can be used to investigate the carbohydrate-protein interactions in highthroughput mode. Carbohydrates can be immobilized on the support surface by covalent or noncovalent binding. The derivatizations of carbohydrates for immobilizing to form glycochips were summarized herein.