Medicinal Chemistry - Volume 21, Issue 1, 2025

BackgroundGlobally, parasitic diseases are considered among the neglected diseases. Clinically, several drugs are used in treatment, however due to drug resistance and multidrug resistance and the low investment in new research lines, there has been a failure in the treatment of parasitic illnesses.ObjectivesThe present mini-review is a comprehensive review of the use of platinum group metals as biological agents. It aims Read More

ObjectivesThiophene is one of the most important heterocyclic scaffolds with notable pharmacological properties. Thiophene and its derivatives are of particular interest among sulphur-containing heterocycles because of their similarities to numerous natural and synthetic compounds with identified potential. The purpose of this study is to extensively analyse the synthetic pathways adopted for synthesising thiophene deriva Read More

IntroductionFuroxan and benzofuroxan are compounds containing an N-oxide function, known for their diverse pharmacological properties, including antimicrobial and anti-inflammatory effects. This study aimed to investigate these activities using an in-house library of N-oxide compounds.MethodsTwenty compounds were tested against both Gram-positive and Gram-negative bacteria, including Cutibacterium a Read More

BackgroundChagas disease has an ineffective drug treatment despite efforts made over the last four decades. The carbonic anhydrase of Trypanosoma cruzi (α-TcCA) has emerged as an interesting target for the design of new antiparasitic compounds due to its crucial role in parasite processes.ObjectiveThe aim in this study was identify potential α-TcCA inhibitors with trypanocidal activity.MethodsA maximum common Read More

IntroductionChalcone compounds exhibit diverse bioactivities, attracting significant interest. Morpholine is a heterocycle commonly used in medicinal chemistry. It could enhance the potency, pharmacokinetics, and bioactivities of its compounds.MethodsAdding morpholine into the chalcone scaffold could help create new compounds with favorable bioactivities. In this study, a new parallel synthesis procedure has be Read More

BackgroundFlavonoids express a wide range of medicinal properties, our study presented results on the anticancer activity of selected compounds using in silico studies.ObjectiveIn this article, in silico studies were carried out to find promising anticancer lead among selected flavonoid compounds.MethodsHere, we carried out molecular docking and MD simulation for anticancer screening of flavonoid derivatives against Read More