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Current Status of Virtual Screening as Analysed by Target Class
- Source: Medicinal Chemistry, Volume 2, Issue 1, Jan 2006, p. 89 - 112
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- 01 Jan 2006
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Abstract
In silico virtual screening for drug discovery has become a hot topic in medicinal chemistry research during the last 5 years, growing from a largely academic pursuit concerned principally with validating the methods used, to a major early-stage technique for lead discovery in the pharmaceutical industry. In this review we highlight a few recent successes in ligand docking associated with virtual screening, paying particular attention to four major target classes of pharmaceutical interest (G Protein-Coupled receptors, nuclear hormone receptors, kinases, proteases). We also discuss some emerging trends in the field, some common limitations, and how they are being overcome.
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