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2000
Volume 2, Issue 1
  • ISSN: 1573-4064
  • E-ISSN:

Abstract

In silico virtual screening for drug discovery has become a hot topic in medicinal chemistry research during the last 5 years, growing from a largely academic pursuit concerned principally with validating the methods used, to a major early-stage technique for lead discovery in the pharmaceutical industry. In this review we highlight a few recent successes in ligand docking associated with virtual screening, paying particular attention to four major target classes of pharmaceutical interest (G Protein-Coupled receptors, nuclear hormone receptors, kinases, proteases). We also discuss some emerging trends in the field, some common limitations, and how they are being overcome.

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/content/journals/mc/10.2174/157340606775197750
2006-01-01
2024-11-23
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  • Article Type:
    Research Article
Keyword(s): docking; GPCR; kinase; protease; receptors; review; Virtual screening
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