Letters in Organic Chemistry - Online First

Premna odorata is a plant species with various medicinal properties. However, in Central Vietnam, the seeds of this plant have not been previously studied for their chemical constituents. The aim of this study was to isolate and identify compounds from the seeds of P. odorata collected from Phu Yen province, Vietnam. The seeds were extracted using dichloromethane. The chemical constituents were isolated and purified. Their st Read More

Dibenzocarbazoles are a class of important materials used in optoelectronic devices. Their simple and practical construction, therefore, holds great potential from both academic and industrial application aspects. However, the conventional synthetic methods for these compounds often suffer the inadequacies, such as tedious synthetic processes, harsh reaction conditions, limited substrate scope, and high cost. Considering the Read More

Isoalloxazines are the essential cofactors of flavoproteins, which are responsible for the different redox reactions in various biological processes. They can be efficiently synthesized using N-substituted 2-nitrophenylamines as a precursor. In the present communication, we report a simple and efficient method for the synthesis of N-substituted 2-nitrophenylamines in DABCO-based ionic liquids. The method offers the use of DAB Read More

A novel synthesis of cryptophycin unit A in its enantiomerically pure form was achieved. In five steps, an enantiomeric mixture of unit A was initially prepared from trans-cinnamaldehyde. Subsequently, in its enantiomerically pure forms, unit A was prepared from Rocher’s ester in six steps, involving an essential aldehyde (2R,3E)-2-methyl-4-phenylbut-3-enal. The final step of this process involved two different approaches: a Read More

5-amino-3-hydroxy-1-phenyl-1H-pyrazol and 3-amino-5-hydroxy-1-phenyl-1H-pyrazol are widely used as synthons in organic and pharmaceutical chemistry. We developed a high-yield synthesis method for 5-amino-3-hydroxy-1-phenyl-1H-pyrazol using high-pressure and base catalysis, achieving up to 80% yield. This method significantly outperforms existing techniques, which yield no more than 39%. The synthesis was Read More

We present a protocol for the synthesis of 3-aminopyrazoles through an eco-friendly cyclocondensation reaction of α-oxo ketene-N, S-acetals with hydrazine hydrates. The reaction runs by using H2O as a solvent to give access to a library of 3-aminopyrazole derivatives (25 examples) under mild and operationally simple conditions. In this study, the green synthesis method showed various fascinating advantages, such as goo Read More

Indole and its derivatives are important in both biology and chemistry due to their presence in many natural compounds and their role in various bodily functions. Indole is the core structure of several key molecules like tryptophan, serotonin, melatonin, and indole-3-acetic acid (IAA), which are involved in processes like cell signaling, growth regulation, and neurotransmission. Indole-based compounds in plants and animals se Read More

The reduction of ketones to secondary alcohols is an essential reaction in organic chemistry, and various reagents are utilized for this purpose. Herein, we have reported the reduction of ketone using decaborane in conventional as well as microwave-assisted methods in aqueous solution. Different types of aromatic ketones containing distinct functional groups were analyzed. We observed that ketones having an electron-wi Read More