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2000
Volume 22, Issue 7
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

An improved strategy for the synthesis of terbinafine has been developed through the cross-coupling of ()-aminovinyl chloride with -butyl acetylene using 1 mol% of 5% Pd/C as a recyclable heterogeneous catalyst under mild conditions. This is the first report on the Pd/C catalyzed Sonogashira coupling to produce the 99.9% pure terbinafine under mild conditions.

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2025-01-02
2025-07-14
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  • Article Type:
    Research Article
Keyword(s): alkynes; anti-fungal; Blanc reaction; Palladium; Sonogashira reaction; terbinafine
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