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2000
Volume 22, Issue 5
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

In pharmaceutical research and drug design, five-membered heteroaromatic ring-fused pyridine derivatives are becoming more common. The pyridine moiety is prone to ring fusion and substitution because it is basic, soluble in water, stable, and able to establish hydrogen bonds. Because of their diverse variety of biological actions, pyridine and thiadiazole have become intriguing possibilities in medicinal chemistry. The water solubility of pharmaceutically promising compounds is often improved by pyridine scaffolds with low basicity, which has also contributed to the development of several broad-spectrum medicinal medicines. Considering these, this manuscript offers a thorough investigation of the synthesis and variety of biological activities displayed by derivatives of pyridine thiadiazole derivatives. The manuscript summarizes different synthetic approaches utilized in the synthesis of these fused compounds and provides insight into their possible pharmacological uses by conducting a comprehensive assessment of recent literature. The complex relationship between biological significance and chemical synthesis provides novel treatment approaches and medication development opportunities.

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2025-07-26

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Synthetic Strategies and Pharmacological Significance of Pyridine Thiadiazole Derivatives: A Contemporary Overview
Lett. Org. Chem. 22, 348 (2025); https://doi.org/10.2174/0115701786324821241113054029
/content/journals/loc/10.2174/0115701786324821241113054029
/content/journals/loc/10.2174/0115701786324821241113054029
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  • Article Type:     Review Article
Keyword(s): heterocyclic chemistry; Isomers; medicinal chemistry; Pyridine thiadiazole; ring fusion; thiadiazole ring

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