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image of Synthesis of (2R,6R,10R)- and (2S,6R,10R)-Pristanic Acid Diastereomers

Abstract

In this study, the synthesis of (2,6,10) and (2,6,10) diastereomers of pristanic acid is described. The key step in this synthesis is the dehomologation of (3,7,11)-dihydrophytol to one-carbon shorter (2,610)-pristanic acid using -iodoxybenzoic acid. The diastereomeric mixture of pristanic acid is easily separated by silica gel column chromatography after conversion to the corresponding amides, which can be converted back to (2,6,10)- and (2,6,10)-pristanic acids in good yields.

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/content/journals/loc/10.2174/0115701786370905250228040842
2025-03-03
2025-04-06
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