Letters in Organic Chemistry - Volume 20, Issue 9, 2023

Polymerase chain reaction is an approach to make numerous copies of specific DNA. PCR has been applied for the investigation of infectious sicknesses caused by viral, protozoan, bacterial, fungal, or other infectious factors. This review manuscript aims to survey the usage of PCR, LAMP, RPA, and RAA in rapid detection and highlight molecular detection of various diseases and pathogens. Scientific sources like Science Dire Read More

It is common knowledge that cancer is the world's biggest cause of mortality. This has led to the ongoing introduction and validation of new cancer therapy outcomes. Benzimidazole derivatives control DNA stability and cell cycle advancement. A heterocyclic nucleus is structurally more favourable for a direct DNA connection and, thus, for the management of the DNA replication process. This review seeks to explore the Read More

The severe acute respiratory syndrome caused by the SARS-CoV-2 virus that instigated the COVID-19 outbreak has been classified as a public health emergency of major global importance. As we know, heterocyclic compounds have been used to treat diseases like viral infections, AIDS, and cancer for many decades. There is a significant opportunity to investigate these heterocycles to combat coronaviruses. In this conn Read More

The main purpose of the present study is to check the therapeutic role of Amaranth squalene against skin cancer by performing docking studies with TGF-β, MIA and Raf which are important target proteins of signal transduction pathways leading to skin cancer development in human beings. In accordance with the World Health Organization, one of the leading causes of death worldwide is cancer. Discovering alternative, econ Read More

An efficient one-pot synthesis of the benzimidazoles and benzothiazole has been developed from the reaction between 1,2 phenylenediamine and 2-aminothiophenol compounds via DMF and DEF as C1 source in the presence of Mukaiyama Reagent (CMPI) as a new organocatalyst. This method was designed based on the principle of green chemistry to avoid the use of any expensive and toxic transition-metal catalyst. All product Read More

A new 4-amino-5-mercapto-3-[(1H-indol-3-yl)propyl]-1,2,4-triazole was synthesized from the fusion of indole-3-butyric acid with thiocarbohydrazide. The reaction of 1,2,4-triazole with a series of benzaldehydes afforded the corresponding Schiff bases (2a-2s). All the synthesized compounds were evaluated for their antibacterial activities using a 96-well microbroth dilution assay. The results of the antibacterial activity revealed that Read More

A new phenol derivative, 3-butyryl-2,6-dihydroxy-4-methoxyphenethyl acetate (1) and seven known phenol analogs (2-8) have been isolated from Arctic fungus Phoma muscivora CPCC 401424. Their structures were elucidated by means of extensive spectroscopic analyses (HRMS, NMR, and IR), and comparison with reported data. All compounds were obtained from Phoma muscivora CPCC 401424 for the first time. Compoun Read More

Microwaves have been used to produce a practical, high-yielding, and scalable synthesis method for producing disubstituted 2H-indazoles. With this technique, a large class of 2H-indazoles can be effectively produced from substituted 2-bromobenzaldehyde, aromatic amine and NaN3 using [Cu(phen)(PPh3)2]NO3 as catalysts. With outstanding purity and yields, the current one-pot synthetic sequence enables the addition of t Read More

A novel series of coumarin-benzimidazole hybrids were designed, synthesized, and extensively characterized using spectral data, including FT-IR, 1H-NMR, and 13C-NMR. Weatherburn's method was used to test new compounds' inhibition of urease activity. The results were evaluated by considering the effects of different side groups and hybridization. The chlorine atom in the molecules notably affects the inhibitory activit Read More

We herein present the synthesis of 1-(1,3-diphenyl-1H-pyrazol-4-yl)-3-(2-hydroxysubstituted phenyl) propane-1,3-dione using microwave irradiation. Reactions were carried out by employing a solvent-free path using K2CO3 as green solid support. The results were compared with those of the conventional method. This microwave-assisted synthesis avoids hazardous solvents and reduces the number of steps and time, providin Read More

Urea derivatives are an important class of pharmacologically-active compounds due to their ability to form hydrogen bonds with biological targets. Several synthetic pathways have been developed to access urea derivatives, such as the metal-free and metal-catalysed carbonylation reactions of amines and the Curtius, Hofmann, and Tiemann rearrangement reactions. This study aimed to synthesize urea derivatives from primary Read More

The present work describes the synthesis of cis-3-(substituted acetoxy)azetidin-2-ones from cis-3-hydroxyazetidin-2-ones. Two different routes have been investigated for the substitution at the C-3 position of the azetidin-2-ones. Method A involves the use of acetyl chloride XCOCl in the presence of pyridine and method B consists of using appropriate acid XCOOH in a catalytic amount of DMAP which was found to be the best to fur Read More