Letters in Organic Chemistry - Volume 20, Issue 11, 2023

A newly designed heterogeneous copper catalytic platform immobilizing copper (II) salt on chitosan Schiff base-modified carbon nanotubes was developed (Cu@CS-Py@CNT). The structure of the catalyst platform was fully characterized by spectroscopic analyses. The catalytic activity of the Cu@CS-Py@CNT was investigated in a one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles by the regioselective click reaction using vari Read More

Irritant, expensive, or toxic desulfurating agents are usually used in the synthesis of isothiocyanates from amines, CS2, and appropriate bases, accompanied by a tedious workup. A more practical and green method has been developed. Cheap and non-toxic CaO was used as both a base and a desulfurating agent in the synthesis of isothiocyanates. Both alkyl and aryl isothiocyanates are easily synthesized in moderate to hi Read More

Marine-derived macrolides that occur naturally exhibit a range of biological properties, including antibacterial and antifungal activity. Sharpless epoxidation and intramolecular acylation via the Friedel-Crafts method for the macrolide ring formation was used as the main steps in the regioselective construction of naturally existing xestodecalactone C, which was started from chiral propylene oxide. The isolated yellow Read More

In the past few years, scientists have learned more about how the human body uses Damino acids and how their synthesis occurs. This has rekindled interest in researching them. D-amino acids are known to be important in an extensive variety of physiologic operations taking place inside the human body. The correlation between these radicals and the physiology of human beings is that Daspartate and D-serine affe Read More

Based on various research reports, pyridine possesses a wide range of pharmacological activities along with many other industrial applications. Because of its diverse applications, pyridine moiety is the center of attraction for researchers, and many patents have been granted focusing on it. Several synthetic protocols, such as cyclo-condensation, cyclization, cycloaddition, electrolysis, etc., were used by researchers to synthe Read More

Following the success of the first intermolecular cyclopropanations of diazo acetoxy acetone with olefins using a novel p-nitro-Ru(II)-diphenyl-Pheox catalyst, other α-functionalized diazoketones have synthesized using the same reaction conditions. Consequently, chiral cyclopropyl products were formed with excellent yield (up to 87% yield), high diastereoselectivity (up to 99:1), and high enantioselectivity (up to 90% ee).

In this study, synthesis of ferrocenylimidazo[1,2-a]pyridine-3-amines was reported from the condensation reaction of ferrocenecarboxaldehyde, 2-aminopyridine, and isocyanides using ZrO(NO3)2.2H2O as an efficient, new, and reusable catalyst under reflux conditions in ethanol. The structures of the products were confirmed by IR, 1H NMR, 13C NMR, and elemental analysis. Quantum theoretical calculations for the structure of Read More

In the current study, a simple and reliable technique for the synthesis of 2,5-disubstituted 1,3,4-thiadiazoles from ethylbenzimidate and benzothiohydrazides were devised. This protocol goes via a base-mediated nucleophilic addition elimination process, followed by intramolecular rearrangement. Our method utilizes commonly accessible and non-toxic substrates and a simple workup procedure to produce high to e Read More

In this study, a continuous flow reactor was used to synthesize Ru nanoparticles with a well-distributed size and good stability. The effects of reactant dilution and flow rate on the synthesis were investigated, and it was found that optimization of these parameters was critical in obtaining small-sized Ru nanoparticles using a solution of 0.00025 M RuCl3.3H2O and 0.001M NaBH4 at a flow rate of 30mL/h. The Ru nanoparticle Read More

The conventional mixed acid nitration of aromatic hydrocarbons has been extensively applied in the industry, but usually, it is not highly selective and may cause environmental concerns regarding the disposal of large volumes of mixed acids. This paper proposes a new method of orientational para-nitration of easily hydrolyzable aromatic compounds. Under the optimized reaction conditions, the easily hydrolyzed aromatic com Read More