Letters in Organic Chemistry - Volume 20, Issue 4, 2023

The presence of N-heterocyclic ring systems as promising features in the molecular skeleton of FDA-approved drugs, underlie the remarkable contributions of these heterocyclic nuclei in the field of medicine. Despite instability risks associated with the COVID pandemic, the US FDA approved 50 drugs (36 NMEs and 14 biological products) in the year 2021. The active ingredients of 32 drugs out of these 36 NMEs (alm Read More

Breast cancer is one of the most frequent invasive malignancies in women globally and the leading cause of mortality. The HER2 target is an important therapeutic option for treating breast cancer. In the present study, efforts have been made to virtually screen the natural kinase inhibitors through molecular docking. A total of 800 HER2 protein inhibitor compounds were selected to screen out the potential inhibitor Read More

The pyrazolone subordinate, aminopyrine, has been broken down tentatively and hypothetically for its vibrational frequencies. The chemical shift values and symphonious vibrational frequencies as obtained at B3LYP/CAM-B3LYP/6-31G after employing proper scaling techniques appear to match acceptably with the test perceptions. The hypothetical spectrograms for NMR, FT-IR and UV spectra of aminopyrine have been lik Read More

A series of fused 3-[{(1-aminomethyl)-5,7-dimethyl-2-oxoindolin-3-ylidene}amino]-2- phenylquinazolin-4(3H)-ones 4(i-ix) has been designed and synthesized by the condensation reaction between 3-amino -2-phenylquinazolin-4(3H)-one and 5,7-dimethylindolin-2,3-dione, followed by aminomethylation with secondary amines in the presence of formaldehyde and were also screened for their antifungal potential against Read More

A novel series of 2, 6-diaryl-3-(4-methylpiperazin-1-yl) piperidin-4-one (2a-2f) derivatives was synthesized. All the synthesized compounds were characterized by FT-IR, NMR, Mass spectrum, and CHN analysis. NMR spectral analyses were performed unambiguously by their one-dimensional (1H NMR and 13C NMR) and two-dimensional (1H-1H COSY and 1H-13C HSQC) NMR. From the NMR spectral data, the compounds (2a-2f Read More

Background: Cancer has become a significant universal health problem. Anticancer drugs control the chemicals that sacrifice cancer cells by inhibiting their growth in their cell cycle. Interestingly, as much as boron nitride nanosheets and boron nitride nanotubes are degradable and non-toxic, they can act as suitable drug carriers for antitumor drugs and deliver them into target cells. Objective: In the present study, the e Read More

This research paper presents a green, safe and easy synthesis of trans-chalcones under ultrasound irradiation in the presence of anionic resins. Several trans-Chalcones have been obtained following an environmentally friendly methodology using Amberlyte IRA-410 and Amberlyte IRA-400 resins as heterogeneous and efficient catalysts. The products of the condensation reaction were generally synthesized in good yields an Read More

The process of hydrogen bond donor accelerating the cycloaddition of epoxides with CO2 is green access to high economic value cyclocarbonate derivatives. However, hydrogen bond donor still has certain limitations such as poor biocompatibility and narrow substrate scope. Our group found that folic acid could promote the coupling reaction of epoxides and CO2 through hydrogen-bonding. The reaction was used to synthesize Read More

Increasing microbial resistance has become a threatening situation for humanity. Therefore, new active antimicrobial compounds are needed to be synthesized. Copper complexes, one of these types of biologically active compounds, appear as compounds with a wide range of biological uses. Many scientific investigations have shown that copper complexes have antibacterial, antimalarial, anti- inflammatory, and anticancer ac Read More