Letters in Organic Chemistry - Volume 20, Issue 6, 2023

A base-promoted cascade reaction of α-ketoester with benzylidene-malononitrile was developed under mild reaction conditions, which enabled the synthesis of polyfunctionalized 2-amino- 3-cyano-4H-pyrans containing ester motifs at 6-position with good to excellent yields. These transformations not only construct various polyfunctionalized 4H-pyrans, which add a new member to the family of 4H-pyrans, but also Read More

Influenza A viruses have caused worldwide epidemics and pandemics by reassortment and generation of drug-resistant mutants, which leads to an urgent need to develop novel antivirals. In this study, a series of sulfonyl piperazine nucleozin derivatives were designed and synthesized, and their in vitro anti-influenza activity was evaluated. Many of these compounds exhibited moderate to good anti-influenza activity against influe Read More

Hydroxy-substituted anthraquinones are among the most important derivatives in organic synthesis. The attractive biological properties of these compounds are relevant to many therapeutic areas that are of use in clinical applications. In this study synthesized several amino-substituted anthraquinones were synthesized from 1,4-dihydroxyanthraquinone using a modified Marschalk reaction. Moreover, 1,4,5-trihydroxyant Read More

Background: In order to synthesize benzoxazin-4 (3H) -one derivatives, a new inorganic- organic super-magnetic nano-hybrid (γ-Fe2O3@ CPTMS-DETA @SO3H) nanocatalyst of the modified sulfuric acid represents a green and efficient catalyst to perform a three-component condensation reaction between various acyl chlorides, anthranilic acid and acetic anhydride (as cyclization agent), in one-pot and solvent-free conditio Read More

An effective organocatalyzed ipso-hydroxylation of arylboronic acids for the preparation of phenol derivatives has been demonstrated. The elucidated phenomenon relies on the catalytic performance of 3-nitropyridine under the influence of sub-stoichiometric quantities of KOtBu employing aerobic conditions in DMSO solvent. This method excludes the excess usage of oxidizing agents and bases by providing a use Read More

Herein, we have reported an efficient synthesis of 2-aryl benzimidazoles by reacting ophenylenediamines and substituting aromatic aldehydes using SO42−/ZrO2-TiO2 as a heterogeneous catalyst. This methodology is straightforward to obtain 2-aryl benzimidazoles with good to excellent yields. It has been performed in ethanol as a green solvent. The reported protocol has some advantages such as a safe and reusable heterogene Read More

Valorization of agricultural waste to produce value-added products such as nanocellulose is important in bringing sustainable development and reduce our dependence on petroleumbased products which are harmful to our environment. The present work is carried out to investigate the potential of the pseudostems from the wild Musa spp. as a novel sustainable source of cellulose nanocrystal (CNCs). TEMPO-mediated o Read More

Visible light has come to the fore in organic chemistry as a cheap and readily available energy source. Energy transfer reactions represent the future directions for the development of practical and scalable industrial reactions with several environmental benefits. A facile, economic, and visible light (CFL) induced synthesis of perimidines has been established through a cyclo-condensation reaction of 1,8-diaminonaphthale Read More

Karanjin (1) is a natural furanoflavonol derivative isolated from seeds of Pongamia pinnata (L.) Pierre. In this paper, we have accomplished a concise total synthesis of karanjin (1) as well as its natural analogues pongapinnol D (2), 3-hydroxy-6-methoxy-2-phenyl-4H-furo[2,3-h]-1-benzopyran- 4-one (3) and 3,6-dimethoxy-2-phenyl-4H-furo[2,3-h]chromen-4-one (4). One-pot aerobic oxidation was the key step to affo Read More

In the present study, we have introduced an efficient solvent-free protocol for the synthesis of glycosyl annulated phosphorylated/thiophosphorylated 1,2,3-triazole derivatives using reusable CuFe2O4 magnetic nanoparticles as a heterogeneous catalyst with the protocols of popular click chemistry approach. Quantum chemical calculations of all the reactants and products have been calculated us Read More

The aim of this study is to isolate and identify new chemical constituents from Cordyline fruticosa (L.) A. Chev. growing in Vietnam. Cordyline fruticosa (L.) A. Chev. (Synonym: Cordyline terminalis L. Kunth), belongs to the Asparagaceae family, is one of the popular plants in folk medicine. This plant has been used to treat various diseases, such as sore throat, neck pain, bloody urine, kidney diseases, headache, infections of Read More