Letters in Organic Chemistry - Volume 20, Issue 7, 2023

A series of pyranopyrazoles were synthesized via a one-pot four-component approach. The reaction was catalyzed by a β-CD/Yb(OTf)3 dual catalytic system. The protocol demonstrated offers several advantages such as short reaction times, excellent yields, good functional group tolerance, ambient and environmentally benign conditions, scalability and simple purification. Such dual catalytic systems are an attracti Read More

A rapid and facile one-pot three-component synthesis of biologically active 6-amino-5- cyano-4-aryl-1,4-dihydro pyrano[2,3-c] pyrazoles was developed using chitosan-p-toluene sulfonate (CS-p-TSA) as a biodegradable catalyst in an aqueous medium. The products synthesized were characterized by FT-IR, 1H-NMR, and 13C NMR. The catalyst was stable and could be used for five cycles without much change in the cat Read More

A series of N-(furan/thiophene/pyrrole-2-yl-(2-hydroxynaphthalen-1-yl)methyl) acetamide derivatives 4 has been depicted by one-pot three-component synthesis using 2- naphthol 1 with aldehydes 2 and amides 3 in the presence of DBU as a catalyst in ethanol as solvent under reflux condition for 110-120 min. This method has the advantages of good yields, being environmentally friendly, straightforward protocol, sho Read More

An iodobenzene diacetate (IBD)-mediated simple and green method was determined for the intramolecular oxidative cyclization of 3-aryl-2-pyridiylhydrazones of different aromatic aldehydes in an aqueous medium at room temperature. This efficient strategy provides a route to the synthesis of 3-aryl-1,2,4-triazolo[4,3-a]pyridines in water which eliminates the requirement to use costly and unsafe volatile organic solv Read More

Chicory, or ‘Cichorium intybus’, is an erect perennial herb that can be used to treat a variety of diseases, including enteric sickness, diabetes, haemorrhoids, malaria, allergies, digestive issues, and more. The enzyme, called 6G-FFT, uses 1-kestose as a substrate for the synthesis of the more complex and branched fructans. To understand the residues involved in this conjugation reaction between 6G-FFT and 1-kestose, Read More

In the growing field of heterocyclic compounds, phenothiazine and the associated nucleus are among the most significant potential scaffolds with excellent pharmacological activities. The knowledge of chemistry, synthetic routes, and various physicochemical parameters of these compounds draws particular attention to create a chemical library. Related compounds synthesized by various routes have diverse pharmacological Read More

New non-symmetric liquid crystal dimers, N-(4-(n-(4-(benzothiazol-2-yl)phenoxy) alkyloxy) benzylidene)-2,4-difluoroaniline (DSFCn), containing two mesogenic core units of benzothiazole and benzylideneaniline were reported. The core system was connected by a flexible alkyl spacer, -(CH2)n-(where n =2-6, 8, 10, and 12). The spectroscopic techniques were employed to confirm the molecular structure of the title compounds. Read More

A new series of metallophthalocyanines (MPc) containing metals such as : Zn (II), Cu (II) and, Pd (II) were designed, synthesized, and characterized, using MS, IR and UV-Vis spectroscopy. A Suzuki cross-coupling reaction was investigated by using the Pd(dppf)Cl2 as a catalyst and cesium carbonate as a base to improve the yield of the precursor 2.6-di(pyridin-3-yl)- phenyl benzyl ether. The changes of metals, substituents, Read More

In this study, the interaction of Melphalan, which is an anti-cancer medicine, with Singlewall carbon nanotubes (SWCNTs) and Boron nitride nanotubes (BNNTs), was investigated. Calculations were performed by using two methods of quantum mechanics and molecular mechanics. Thermodynamic parameters and Frontier Molecular Orbitals (FMOs) of the title compounds were evaluated by using the Density Functio Read More

Memantine hydrochloride (MH) is a first-line therapeutic drug approved by the US FDA for the management of moderate to severe Alzheimer's disease. This study involves the synthesis of memantine hydrochloride from 1-bromo-3,5-dimethyladamantane through a reaction with thiourea. The research results showed that the solvent reaction was propylene glycol (PG); the total time reaction was 5.5 hours, the temperature Read More

Globally, chronic diseases are becoming the leading cause of death. Because of the large number of patients, high medical cost, long duration of illness and the great demand for services. Diabetes is one of them and the prevalence is still rising, causing a serious physical burden to patients; it also affects a great economic burden on society. Therefore, the development of more effective antidiabetic medication is of great impor Read More