Synthesis of Some New 1,2,4-triazole Schiff Bases and their Antibacterial Activity Studies

A new 4-amino-5-mercapto-3-[(1H-indol-3-yl)propyl]-1,2,4-triazole was synthesized from the fusion of indole-3-butyric acid with thiocarbohydrazide. The reaction of 1,2,4-triazole with a series of benzaldehydes afforded the corresponding Schiff bases (2a-2s). All the synthesized compounds were evaluated for their antibacterial activities using a 96-well microbroth dilution assay. The results of the antibacterial activity revealed that Schiff base 2p with both chloro groups at meta and para positions of the phenyl exhibited significant inhibition against Bacillus cereus and Staphylococcus aureus at MIC 9.11 μmol/mL and against Bacillus subtilis spizizenni at 18.20 μmol/mL.