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- Volume 25, Issue 8, 2019
Current Pharmaceutical Design - Volume 25, Issue 8, 2019
Volume 25, Issue 8, 2019
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Modulation of CD44, EGFR and RAC Pathway Genes (WAVE Complex) in Epithelial Cancers
Authors: Pranathi Tata, Piyush Gondaliya, Aditya Sunkaria, Akshay Srivastava and Kiran KaliaCancer hallmarks help in understanding the diversity of various neoplasms. Epithelial cancers play an immense role in the tumor biology through Epithelial-Mesenchymal Transition (EMT) process. Receptor tyrosine kinase, as well as phosphatidyl ionositol-3 kinase pathways, play an important role in the regulation of cell proliferation, survival, and differentiation during EMT. Till date, numerous studies have shown modulation in Read More
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Inhibition of Heat Shock Protein 90 as a Novel Platform for the Treatment of Cancer
Authors: Chang Gao, Ya-Nan Peng, Hai-Zhou Wang, Shi-Lin Fang, Meng Zhang, Qiu Zhao and Jing LiuHeat shock protein 90 (Hsp90) plays an essential role in various physiological and pathological processes. It activates client proteins to participate in tumor progression. Blocking Hsp90 could enable effective antitumor effects in many tumor types, such as multiple myeloma and colon cancer. Recently, it has motivated an interest in Hsp90 inhibitors that bind to the N-terminal or C-terminal ATP pocket as antitumor drugs. We re Read More
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The Regulatory Roles of Long Non-Coding RNA in the Chemoresistance Process of Ovarian cancer
Authors: Jiayuan Qu, Mohammad A. Kamal and Chengfu YuanBackground: Ovarian cancer is the most malignant tumor in gynecological tumors, with low five-year survival rate. The main reasons are diagnosis at advanced stages (the early symptoms are uncharacteristic, and most are diagnosedlate.), relapse, and resistance to existing chemotherapy drugs. Methods: Search strategy was performed in the following steps. Firstly, LncRNA related to ovarian cancer was retrieved by using t Read More
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Evaluation of Local Injection of Bevacizumab against Triple-Negative Breast Cancer Xenograft Tumors
Authors: Xin Jiang, Qiao-Li Zhang, Tie-Gang Liu, Wei-Peng Zhao, Ming Yang, Li-Na Wang, Wei-Liang Sun, Lin Pan, Ai-Ping Luo, Jin-Chang Huang and Xiao-Hong GuBackground and objective: Bevacizumab (BVZ) is a recombinant humanized antibody that inhibits the vascular endothelial growth factor A (VEGFA) and is used for the treatment of various types of cancer. BVZ is primarily given by the intravenous drip (I.V.), which often leads to low efficacy and various side effects. Therefore, the present study was to evaluate the effect of local delivery of BVZ against triple-negative breast cance Read More
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Ethnobotany, Phytochemistry and Traditional Uses of Curcuma spp. and Pharmacological Profile of Two Important Species (C. longa and C. zedoaria): A Review
Ethnopharmacological relevance: The genus Curcuma, which is the most important source of curcumin, has been widely used in different traditional medicines. Various species of Curcuma have long been used for several purposes such as healing wounds, liver disorders, jaundice and also as a blood purifier. Aim of the study: This review focused on the ethnopharmacological uses and phytochemical aspects of Curcuma Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
- Issue 46
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- Issue 1
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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