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- Volume 25, Issue 42, 2019
Current Pharmaceutical Design - Volume 25, Issue 42, 2019
Volume 25, Issue 42, 2019
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Methods for the Determination of the Purity of Exosomes
Authors: Katarzyna Kluszczyńska, Liliana Czernek, Wojciech Cypryk, Łukasz Pęczek and Markus DüchlerBackground: Exosomes open exciting new opportunities for advanced drug transport and targeted release. Furthermore, exosomes may be used for vaccination, immunosuppression or wound healing. To fully utilize their potential as drug carriers or immune-modulatory agents, the optimal purity of exosome preparations is of crucial importance. Methods: Articles describing the isolation and purification of exosomes were ret Read More
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Exosomes in Sepsis and Inflammatory Tissue Injury
Authors: Eun J. Park, Michael G. Appiah, Phyoe K. Myint, Arong Gaowa, Eiji Kawamoto and Motomu ShimaokaSepsis is the leading cause of death in medical intensive care units, and thus represents a serious healthcare problem worldwide. Sepsis is often caused by the aberrant host responses to infection, which induce dysregulated inflammation that leads to life-threatening multiple organ failures. Mediators such as proinflammatory cytokines that drive the sepsis pathogenesis have been extensively studied. Exosomes, biological lipi Read More
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Exosomes: Carriers of Pro-Fibrotic Signals and Therapeutic Targets in Fibrosis
Authors: Mengyu Li, Mao Jiang, Jie Meng and Lijian TaoExosomes are nano-sized extracellular vesicles that are released by a variety of cells. Exosomes contain cargo from cells they derived, including lipids, proteins and nucleic acids. The bilayer lipid membrane structure of exosomes protects these contents from degradation, allowing them for intercellular communication. The role of exosomes in fibrotic diseases is increasingly being valued. Exosomes, as carriers of profibrotic s Read More
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Neurotoxic and Neuroprotective Role of Exosomes in Parkinson’s Disease
Exosomes are extracellular vesicles produced by eukaryotic cells that are also found in most biological fluids and tissues. While they were initially thought to act as compartments for removal of cellular debris, they are now recognized as important tools for cell-to-cell communication and for the transfer of pathogens between the cells. They have attracted particular interest in neurodegenerative diseases for their potential rol Read More
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The Emerging Role of Exosomal Non-coding RNAs in Musculoskeletal Diseases
Authors: Chao Tu, Jieyu He, Ruiqi Chen and Zhihong LiExosomes are phospholipid bilayer-enclosed membrane vesicles derived and constitutively secreted by various metabolically active cells. They are capable of mediating hetero- and homotypic intercellular communication by transferring multiple cargos from donor cells to recipient cells. Nowadays, non-coding RNAs (ncRNAs) have emerged as novel potential biomarkers or disease-targeting agents in a variety of diseases. Read More
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Exosomes and Bone Disease
Authors: Su-Kang Shan, Xiao Lin, Fuxingzi Li, Feng Xu, Jia-Yu Zhong, Bei Guo, Yi Wang, Ming-Hui Zheng, Feng Wu and Ling-Qing YuanExosomes, which mediate cell-to-cell communications and provide a novel insight into information exchange, have drawn increasing attention in recent years. The homeostasis of bone metabolism is critical for bone health. The most common bone diseases such as osteoporosis, osteoarthritis and bone fractures have apparent correlations with exosomes. Accumulating evidence has suggested the potential regenerative capacit Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
- Issue 46
- Issue 45
- Issue 44
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- Issue 42
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- Issue 2
- Issue 1
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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