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- Volume 25, Issue 34, 2019
Current Pharmaceutical Design - Volume 25, Issue 34, 2019
Volume 25, Issue 34, 2019
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Application of Three-dimensional (3D) Tumor Cell Culture Systems and Mechanism of Drug Resistance
The in-vitro experimental model for the development of cancer therapeutics has always been challenging. Recently, the scientific revolution has improved cell culturing techniques by applying three dimensional (3D) culture system, which provides a similar physiologically relevant in-vivo model for studying various diseases including cancer. In particular, cancer cells exhibiting in-vivo behavior in a model of 3D cell culture i Read More
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Biocompatible Polymers and their Potential Biomedical Applications: A Review
Background: Biocompatible polymers are gaining great interest in the field of biomedical applications. The term biocompatibility refers to the suitability of a polymer to body and body fluids exposure. Biocompatible polymers are both synthetic (man-made) and natural and aid in the close vicinity of a living system or work in intimacy with living cells. These are used to gauge, treat, boost, or substitute any tissue, organ or fu Read More
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Switching from Conventional to Nano-natural Phytochemicals to Prevent and Treat Cancers: Special Emphasis on Resveratrol
Authors: Salman Ul Islam, Muhammad B. Ahmed, Mazhar Ul-Islam, Adeeb Shehzad and Young S. LeeBackground: Natural phytochemicals and their derivatives have been used in medicine since prehistoric times. Natural phytochemicals have potential uses against various disorders, including cancers. However, due to low bioavailability, their success in clinical trials has not been reproduced. Nanotechnology has played a vital role in providing new directions for diagnosis, prevention, and treatment of different diso Read More
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Core-Shell Molecularly Imprinted Polymer Nanocomposites for Biomedical and Environmental Applications
Authors: Nasrullah Shah, Saba Gul and Mazhar Ul-IslamCore-shell polymers represent a class of composite particles comprising of minimum two dissimilar constituents, one at the center known as a core which is occupied by the other called shell. Core-shell molecularly imprinting polymers (CSMIPs) are composites prepared via printing a template molecule (analyte) in the coreshell assembly followed by their elimination to provide the everlasting cavities specific to the template mol Read More
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Pollution, Toxicity and Carcinogenicity of Organic Dyes and their Catalytic Bio-Remediation
Water pollution due to waste effluents of the textile industry is seriously causing various health problems in humans. Water pollution with pathogenic bacteria, especially Escherichia coli (E. coli) and other microbes is due to the mixing of fecal material with drinking water, industrial and domestic sewage, pasture and agricultural runoff. Among the chemical pollutants, organic dyes due to toxic nature, are one of the majo Read More
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Comparative Synthesis and Characterization of Bio-Cellulose from Local Waste and Cheap Resources
More LessBackground: Bacterial cellulose (BC) has been extensively utilized in a wide range of applications specifically in the biomedical field thanks to its excellent physico-chemical and biological features. The major limitation restricting its application in certain areas is its high production cost. Its widespread applications demand exploration of alternative production media compared to the existing expensive ones. Herein, an effort Read More
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Preparation and Characterization of Agar Based Magnetic Nanocomposite for Potential Biomedical Applications
Authors: Nasrullah Shah, Tahir Zaman, Touseef Rehan, Salman Khan, Waliullah Khan, Abbas Khan and Mazhar Ul-IslamPurpose: The purpose of the present study was to make a biocompatible agar based composite material via incorporation of appropriate additives within the agar matrix for potential applications in drug delivery and biomedical fields. Methodology: Agar based composites were prepared by the incorporation of magnetic iron oxide nano particles, graphite and sodium aluminum as additives in different proportions within the agar Read More
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Apoptosis of Leukemia Cells by Ocimum basilicum Fractions Following TNF alpha Induced Activation of JNK and Caspase 3
Purpose: Leukemia, one of the major cancers, affects a large proportion of people around the world. Better treatment options for leukemia are required due to a large number of side effects associated with current therapeutic regimens. In the present study, we sought to determine the pathway of triggering apoptosis of leukemic cells by Ocimum basilicum (O. basilicum) plant extract. Materials/Methods: Methanolic extra Read More
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Functionalized Bacterial Cellulose Microparticles for Drug Delivery in Biomedical Applications
Authors: Hanif Ullah, Munair Badshah, Alexandra Correia, Fazli Wahid, Hélder A. Santos and Taous KhanBackground: Bacterial cellulose (BC) has recently attained greater interest in various research fields, including drug delivery for biomedical applications. BC has been studied in the field of drug delivery, such as tablet coating, controlled release systems and prodrug design. Objective: In the current work, we tested the feasibility of BC as a drug carrier in microparticulate form for potential pharmaceutical and biomedical Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
- Issue 46
- Issue 45
- Issue 44
- Issue 43
- Issue 42
- Issue 41
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- Issue 31
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- Issue 28
- Issue 27
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- Issue 25
- Issue 24
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- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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