Current Pharmaceutical Analysis - Volume 18, Issue 9, 2022

Epilepsy is one of the chronic diseases seen in 1.0% of the world’s population. For the study of antiepileptic medications, a variety of approaches have been used extensively. These methods provide reliable, accurate, and reproducible results. The available analytical methods for the determination of AEDs in API, biological fluids, and pharmaceutical formulations are reviewed in this context. The drugs categorized und Read More

Background: Digoxin, a cardiac glycoside, is one of the most significant drugs of choice for treating congestive heart failure. As digoxin is a BCS class IV drug, dissolution is a critical quality attribute during its solid dosage formulation. Methods: This study aims to quantify the drug release during dissolution for low dosage digoxin of 0.0625 mg tablets with a targeted drug release of more than 80% at 60 minutes. We used a Read More

Background: Early antidepressant Active Pharmaceutical Ingredients (API), like imipramine hydrochloride and clomipramine hydrochloride, have not been assessed for Genotoxic Impurities (GTI) as per ICHM7. Objective: The main aim of the study was to develop a new simple and sensitive method for the determination of genotoxic impurities in imipramine hydrochloride and clomipramine hydrochloride active pharmaceutic Read More

Background: Bispecific antibody (BsAb) therapeutics have emerged as the nextgeneration immuno-oncology therapy. The architecture of bsabs is inherently more complex than that of mAb therapeutics. As a result, prior knowledge of critical quality attributes (CQAs) assessment of mAbs is no longer inclusive for bsabs. Objective: The main objective of this work is to develop a fully automated one-step capillary isoelectric focusi Read More

Guanfacine, an α2-adrenergic (α2A) agonist long indicated to treat hypertension, is now being used to treat attention deficit hyperactivity disorder (ADHD) in adolescents. A simple, rapid high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) method to detect and quantify guanfacine provides a basis for studying its bioequivalence and pharmacokinetics in human plasma. This assay involves quantitation of g Read More

Background: Lung cancer remains one of the leading cancers with increasing mortality rates in the world. The clinicians in our hospital summarized “Fu Zheng Fang (FZF)” as a Chinese medicine prescription with good therapeutic effect and low adverse reactions to treat lung cancer. Objective: This research aimed to conduct an in-depth study on the essence and internal rules of the effect of FZF. Methods: Serum samples from t Read More

Background: Long-term nitroglycerin (NTG) therapy causes tolerance, which limits its clinical application. Previous studies have reported a novel Danshensu/tetramethylpyrazine derivative ADTM, which displays strong cardioprotective effects. However, the effect of ADTM is not known in the NTGinduced tolerance model. In this study, we aimed to evaluate the potential improvement and underlying mechanism of ADTM for pr Read More

Background: Angiotensin II receptor blockers (ARBs) are helpful medications for treating hypertension and heart failure and have been proposed as a possible alternative to standard angiotensin-converting enzyme inhibitors. Objective: The present article describes and validates sensitive hydrophilic interaction liquid chromatography methods to simultaneously analyse four angiotensin II receptor blockers: valsartan, telmis Read More