Current Pharmaceutical Analysis - Volume 18, Issue 1, 2022

Background: Sulfonamides are the anti-bacterial and anti-inflammatory drugs synthesized, which are widely used as medical and veterinary antibiotics. However, the excess dosage of sulfonamides can harm human health. Drug residues in animal products also can harm human health through the food chain. The long-term consumption of animal food containing drug residues will cause some toxicity and side effects on Read More

Background: Glucose detection is of great significance in biomedicine. In clinical medicine, diabetes seriously endangers human health. By accurately measuring the blood glucose content of diabetic patients, diabetes can be effectively monitored and treated. At present, there are many methods for measuring glucose content, such as chromatography, spectroscopy, and electrochemical methods. Among them, electroch Read More

Background: Pain not only affects the quality of life of an individual but can also cause mental illness due to the lack of effective treatment for long-term pain. Analgesics refer to drugs that can partially or completely relieve pain, including non-steroidal anti-inflammatory drugs and central analgesics. Methods: In recent years, the cross integration of electrochemical analysis technology with biochemistry, materials science, Read More

Athletes are not allowed to use performance-enhancing drugs. Despite many efforts, the use of performance-enhancing drugs still persists in sports. Doping testing in athletes is the main way to determine drug consumption. Taking biological samples from athletes can be used to detect doping. The least invasive method is urine, while hair and saliva can be sampled using a minimally invasive procedure. In contrast, blood Read More

Background: Flavonoids are a large class of phenolic compounds, which generally refer to two benzene rings (A ring, B ring) with phenolic hydroxyl groups connected to each other through three central carbon atoms, that is, a series of C6-C3-C6 basic core compounds. Due to its potential medicinal value, the research on flavonoids has aroused great interest. Methods: This review aims to identify the research progress and Read More

The review aims to present the importance of implementing microextraction-, capillary electrophoresis- and ionic liquid-based approaches in biomedical research. These analytical strategies could improve the biochemical diagnosis of various life-threatening diseases, aid in the search for therapeutic agents, and discover drug targets. They could be used when designing newer, safer medicinal products. All the proposed an Read More

Introduction: Asari Radix et Rhizoma (ARR) and dried ginger (Zingiber officinalis) (DG) are often used together in drug preparations in traditional Chinese medicine (TCM) to treat respiratory diseases, including cold, bronchitis and pneumonia. Previous studies suggested that ARR and/or DG may influence the pharmacokinetics of other herbal components. In the current study, we examined pharmacokinetic interactions betw Read More

Aims: To establish a rapid and simultaneous determination of multiple effective ingredients in anti-cold drugs. Background: Anti-cold drugs are stock medicines at home, and most anti-cold formulations are compound preparations. Although the active ingredients of compound preparations have significant effects on the treatment of colds, the excessive dosage or long-term use can produce a series of adverse reactions, including Read More

Background: Aluminum (Al) is classified as other elements by ICH, and its permitted daily exposure (PDE) has not been established. As it might cause compromised renal function, guidelines, regional regulations and practices need to be addressed. According to the United States Pharmacopeia 41 and the Japanese Pharmacopoeia 17, the aluminum content of large-volume parenterals (LVPs) used in total parenter Read More

Introduction: Phillyrin, the main pharmacological component of Forsythia suspensa, exhibits a wide variability of therapeutic activities, such as anti-oxidative stress, free radicalclearing, antibacterial activity, hepatic protection, restoration of endothelial glycocalyx damage, prevention of bone loss, attenuation of inflammatory responses, and so on. Previous research has found that phillyrin is not easily absorbed by the body an Read More

Background: Lipoic acid is the only known chiral antioxidant that is both lipidsoluble and water-soluble. It is often used as a treatment for peripheral polyneuropathy caused by diabetes, alcohol, and chemicals. However, only a few long-term toxicological studies have been conducted on R-α-lipoic acid, which is a bioactive ingredient in lipoic acid. Objective: In this study, a simple, efficient, sensitive and stable LC-MS/MS method was Read More

Background: As an anti-inflammatory prodrug, loxoprofen is metabolized into transloprofenol to treat diseases related to pain and inflammation. Although loxoprofen has fewer adverse effects than other NSAIDs, the safety of its usage during pregnancy remains unclear and needs to be considered. Fortunately, the toxicokinetics and tissue distribution study of transloxoprofen- alcohol in pregnant rats can resolve the probl Read More

Background: The trough concentration (Cmin) of Imatinib (IM) is closely related to the treatment outcomes and adverse reactions of patients with gastrointestinal stromal tumors (GIST). However, the drug plasma level has great inter- and intra-individual variability, and therapeutic drug monitoring (TDM) is highly recommended. Objective: To develop a novel, simple, and economical two-dimensional liquid chromatograph Read More

Background: The risk of toxicity for the healthy individuals who are chronically exposed to cytostatic drugs was established in 1970s. Since then, many institutions have recommended monitoring occupational exposure to antineoplastic agents. Nevertheless, there is still a lack of analytical procedures for this inspection. The prodrug Capecitabine is an example of a cytostatic drug that has never been analyzed for the purpos Read More

Objective: Chemical investigation of the extract of sponge-derived fungus, Aspergillus niger, was performed by liquid chromatography coupled with QExactive mass spectrometry for the first time. Method: A total number of 444 constituents were detected, 288 of which were identified positively or tentatively by the comprehensive utilization of accurate molecular weight and fragmentation information acquired from quadrupole o Read More