Current Pharmaceutical Analysis - Volume 18, Issue 2, 2022

In this review, numerous analytical methods to distinguish pigments in tattoo, paint, and ink items are discussed. The selection of a method was dependent upon the purpose, e.g., quantification or identification of pigments. The introductory part of this review focuses on describing the importance of setting up a pigment-associated safety profile. The formation of different degradation chemical substances as well as imp Read More

Background: The objective of this research was to screen metabolites with specificity differences in the lung tissue of paraquat-poisoned rats by metabolomics technology and chi-square test method, to provide a theoretical basis for the study of the mechanisms of paraquat poisoning, and to use machine learning technology to construct a paraquat poisoning diagnosis model. This provided an intelligent decision-making metho Read More

Background and Objectives: SM-1 is a new synthetic small molecular compound with anti-tumor activity. The metabolism of SM-1 is a key parameter that needs to be evaluated to provide further insight into drug safety and efficacy in the early phases of drug development. Methods: In this study, the biotransformation process of SM-1, including the metabolic pathways and major metabolites, was investigated based on a Read More

Background: Compound Niuhuang Xiaoyan capsule is a realgar and cinnabar-containing traditional Chinese medicine, the contents of total arsenic and total mercury are found over regulation defined limits. However, only small amounts of arsenic in realgar and mercury in cinnabar are dissolved in the gastric juice, so the determination of soluble arsenic and soluble mercury is more significant than that of total arsenic a Read More

Background: Cyclodextrins (CDs) are commonly used host molecules of inclusion complex. However, due to the lack of a sensitive determination method, the absorption process of CDs remains unclear. Objective: In this study, an oleuropein (OL) inclusion complex employing hydroxylpropyl-betacyclodextrin (HP-beta-CD) as host molecules was prepared and the formation of inclusion complex was ascertained by FT-IR and DS Read More

Background: Omeprazole has poor water solubility, is unstable in acidic solutions and undergoes first-pass metabolism, which results in lowering its bioavailability. A solid Self-Nano Emulsifying Drug Delivery System (SNEDDS) was previously prepared to enhance its dissolution. Objective: Development and validation of an RP-HPLC method with UV detection for the determination of omeprazole in 0.1 N HCl and in 0.01 M ph Read More

Background: Thiamine hydrochloride (THY), also known as vitamin B1, is a watersoluble vitamin usually found in food and considered as a dietary supplement and treatment in case of vitamin deficiency, for example, in malabsorption and chronic diarrhea. Objectives: Rapid, green, and sensitive methods for the assay of vitamin B1 (thiamine hydrochloride, THY) in pharmaceutical forms, using normal and reverse flow inj Read More

Background: Extensive therapeutic drug monitoring needs an analytical method for efficient and sensitive quantification of analytes of interest in clinical pharmacology. Objectives: A rapid, robust, sensitive and simple UPLC-MS/MS method to quantify Methsuximide (Ms) and N-desmethyl methsuximide/Normesuximide (MsMET) in human plasma was optimized, developed, and validated for application in a pharmacokinetic Read More

Background: Design of experiment (DOE) is considered the most powerful tool to identify factors that affect variation and improve the response by tuning these factors. In the present work, DOE was applied to establish an innovative, sensitive, and precise HPLC method for the simultaneous determination of Escitalopram oxalate, Paroxetine hydrochloride hemihydrate and Clonazepam in the presence of their related compou Read More