Current Pharmaceutical Analysis - Volume 18, Issue 3, 2022

Abstract: Background: Several analytical approaches for assessing anti-cancer drugs in pharmaceutical formulations have been developed over the last few years. QbD plays an important role in establishing accurate analytical methods to analyze anti-cancer compounds. Quality by Design has become a risk analysis and a science-based strategy, implemented by experimental methods to optimize system output with known vari Read More

Abstract: Brinzolamide is a treatment option for glaucoma. As glaucoma is the third leading cause of blindness, there is a need for analytical methods to obtain an effective drug with great precision and accuracy. Even if brinzolamide is official in IP and USP, different analytical methods still need to be brought in one place, which would help attain better results and easy comparison for other analysis specifications and proce Read More

Background: Hydroxychloroquine (HCQ) was originally launched as an antimalarial drug, but now it is also used as a slow-acting anti-rheumatic drug. It contains equal proportions of (-)-(R)-hydroxychloroquine and (+)-(S)-hydroxychloroquine. Introduction: Hydroxychloroquine, a synthetic 4-aminoquinoline derivative, possesses antimalarial, anti-rheumatic activity and also exerts beneficial effects on lupus erythematous disea Read More

Background: Verapamil is an excellent drug used for the medication of hypertension and trandolapril. It is an angiotensin-converting-enzyme inhibitor. Hence, it is an interesting method to develop a novel and reliable MS/UPLC strategy for the simultaneous development of verapamil and trandolapril. Objectives: This research study aims to develop a new, rapid, and sensitive UPLC-MS/MS method for the simultaneous estim Read More

Background: Bisphenol A (BPA) derivatives monomers as resins are common components in dental restorative materials and materials used for orthodontic treatment. However, they are a source for BP-A leakage, which can affect adult and child health as an endocrine disruptor. Objectives: This study aimed to investigate the level of BPA leakage from four selected weights (0.1, 0.2, 0.3, 0.4 mg) of five different resin combina Read More

Background: To mitigate diabetes and its complications in cardiovascular diseases, the antidiabetic agent Glimepiride (GLM) is usually administered with Ferulic Acid (FA) concomitantly in clinical settings. However, both drugs are prone to be metabolized partly by CYP2C9; thus, they have the potential drug-drug interaction affecting safety and efficacy. Objective: This study aimed to evaluate the Pharmacokinetic (PK) effects of Read More

Background: Minodronic acid (MA) is a third-generation nitrogen-containing heterocyclic bisphosphonate used to treat osteoporosis. In the process of starting materials research and preparation, the key intermediate impurities and degradation impurities have a great impact on the quality control of the drug. Objectives: A sensitive, reliable, high-performance liquid chromatography (HPLC) method was developed and validat Read More

Background: Salviae miltiorrhizae Radix et Rhizoma (Red Sage root) is widely used in traditional Chinese medicine (TCM) for the treatment of Alzheimer’s disease (AD) with demonstrated curative effects, based on the concept of "one drug with multiple therapeutic targets," which appears to be a good strategy for AD treatment. Objective: This study aimed to develop of high-throughput screening (HTS) method for multither Read More