Current Pharmaceutical Analysis - Volume 18, Issue 8, 2022

Since the global spread of covid-19, PCR predominantly has taken the lead in the diagnosis. It amplifies a particular DNA target sequence into millions of copies. To simplify the laboratory- dependent disease diagnosis, the point of care diagnostics (POC) paved the way for labon- a-chip-technology. Succeeding that, POC integrated with PCR stole the limelight. This review points out the various diagnostic methods of covid- Read More

Background: Brexpiprazole (BRZ) is a "third-generation" antipsychotic dopaminergic (D2) and 5HT1A (serotonin) partial agonist, approved in July 2015 by the US Food and Drug Administration for the treatment of the major depressive disorder (MDD) other than schizophrenia in adults. Antipsychotics are known to produce extrapyramidal effects as side effects. The recent development in this segment is of piperazine-ba Read More

Curcumin is a lipophilic polyphenolic yellow compound extracted from Curcuma longa Linn. (turmeric) rhizome with a broad spectrum of pharmacological and medicinal properties as propounded by several in vivo, in vitro, and clinical studies. Considerable research over the past century has been extensively carried out on chemical, biological, and analytical perspectives of curcumin. Nowadays, curcumin is widely Read More

Aims: Syringopicroside (SYR) is an iridoid monomer compound isolated from the leaves of clove. HBV is a hepatotropic virus that can cause severe liver diseases, including acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Syringopicroside has a significant effect on anti-HBV, but its mechanism of action is still unclear. Methods: A metabolomics approach based on UPLC-G2-Si-HDMS was performed to anal Read More

Background: Artemether (ART) has been recognized as a potent and rapidly acting antimalarial agent metabolized by cytochrome P450 isoenzyme 3A4 into a more active form dihydroartemisinin (DHA). Hence, it was required to study the pharmacokinetics and biodistribution of ART and DHA for the optimization of dose. Objective: The current research aims to develop an ultra-performance liquid chromatographytandem mass sp Read More