Current Pharmaceutical Analysis - Volume 14, Issue 2, 2018

Background: Docetaxel is a potent anticancer agent used in various cancer types. Attempts are being made to improve docetaxel's pharmacokinetics because desirable modifications in disposition and biodistribution characteristics could enhance the therapeutic outcomes of the drug. Quantitative analysis of docetaxel in the body is important to understand modifications necessary to improve the drug's biodistribu Read More

Objective: Simple and sensitive UV method was developed and validated for the determination of meclizine hydrochloride in formulation, based on binary complex formation with eosin Y. Method: The absorbance of the formed complex was measured at 540 nm. Beer's law was obeyed in the range of 5-25 μgmL-1 with r2 value 0.9960. Results: The method showed good value of accuracy and precision (%RSD=1.096), and the li Read More

Background: Icariin (ICN) is the main bioactive natural flavonoid in plants of the Epimedium genus and is valued in traditional Chinese medicine owing to its beneficial effects, including enhancement of cardiovascular function and antitumorigenic activity. Current methods for detecting ICN employ expensive instruments that require a high level of skill for operation. As such, a more simple and rapid assay is desired. Methods Read More

Background: Rifaximin is an oral antimicrobial, which, until now, does not have standardized analytical methods in most official compendia. The literature shows few methods for the detection of drug, but has no analytical method for the determination of rifaximin in the pharmaceutical product. The lack of environmentally friendly methods with the use and minimal generation of toxic waste is also a gap. Methods: This w Read More

Background: X22 is one of the imidazopyridine derivatives designed and synthesized in our laboratory. This compound showed excellent anti-inflammatory activity in LPS-stimulated macrophages. We previously investigated the biological activities of X22, including treatment of obesityrelated complications and retinal ischemia/reperfusion injury. Methods: In the present study, a reliable, rapid, and simple UPLC m Read More

Background: Dendrobium officinale (D. officinale) has been traditionally used as an herbal medicine in Eastern Asia. Because of its ambiguous chemical characteristics, an authentic quality evaluation system is urgently needed. The aim of this work is to establish a comprehensive method for the evaluation of D. officinale based on volatile constituents, methanol extracts and polysaccharide analysis. Methods: We identify th Read More

Objective: A simple, reliable and specific method of HPLC which was performed on a reversed- phase Agilent SB column was developed for the determination of imatinib and CGP74588. Method: The mobile phase comprised water-acetonitrile-0.1% trifluoroacetic acid (59:21:20, v/v/v) flowed at the rate of 1 mL/min at 40°C. The detection wavelength was 278nm. Results: Sensitivity has been illustrated in this method, and a goo Read More

Background: Carvedilol (CD) is a β-blocker drug that is used in the treatment of hypertension, coronary diseases, etc. The official methods for the assay of CD in British Pharmacopoeia (BP) and United States Pharmacopeia (USP) include potentiometric titration and HPLC analysis, respectively. There are two different methods reported in the USP; one is for the pure CD and the other is for its tablet dosage forms. Both methods Read More

Background: A precise, accurate, rapid and sensitive reverse phase liquid chromatographic (RP-HPLC) method has been developed in rabbit plasma spiked with Diltiazem hydrochloride (DTZ). Methods: The chromatographic method was standardized using an Agilent 5 TC- C18 column (2) 250 mm x 4.6 mm with UV detection at 237 nm and flow rate of 1 ml/min. The mobile phase consisted of methanol: water (90:10: v/v). The reten Read More

Introduction: A simple, isocratic High Performance Liquid Chromatography (HPLC) method has been modified for the qualitative and quantitative analyses of amisulpride related substances. This method is based on using of RP-C8 (250 4.6 mm) column and a mixture of phosphate buffer and methanol as mobile phase. Materials and Methods: Various forced degradation studies were conducted to establish an impurity profile f Read More