Current Proteomics - Volume 21, Issue 1, 2024

Background: Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck region known for its high metastatic and invasive potential. Chlorpromazine (CPZ) has been shown to inhibit the growth of oral cancer cells. However, the effects of CPZ on OSCC migration and its underlying molecular mechanisms remain unclear. Objectives: We aimed to identify global protein changes and potential core pr Read More

Background: Plasmodium falciparum (P. falciparum) heat shock proteins (PfHSP70s) are an important class of molecules critically involved in parasite survival during stress. Interaction between the cytosolic PfHSP70-1 and a crucial lipid modulator, Phosphatidylinositol 3 Phosphate (PI3P), stabilizes the parasite Digestive Vacuole (DV) to facilitate hemoglobin trafficking and breakdown, in turn impacting parasite survival. Met Read More

Background: Acinetobacter baumannii is an opportunistic pathogen that causes many infections, including nosocomial infections; this bacterium has a high mortality rate among other bacteria. A. baumannii has an elastic genome that changes rapidly when exposed to harsh environmental conditions, leading to widespread bacterial resistance to various disinfectants and antibiotics. The high ability of bacteria to bind to all su Read More

Background: Streptococcus equi ssp. zooepidemicus (SEZ) is one important pathogen. There are still sporadic outbreaks in China, northern United States and the Netherlands. Adenylosuccinate synthetase PurA, a newly discovered protein in prior research, requires further assessment of its protective effectiveness. Methods: In this study, we focused on the expression of recombinant PurA from SEZ ATCC 35246. We evaluate Read More