Current Proteomics - Volume 21, Issue 2, 2024

Monoclonal antibodies (mAbs) are magic bullets proved to be a wonder in the pharmaceutical as well as medical fields. These are produced by various methods like hybridoma technology, phage display technology, YAC technology, and transgenic animals and plants. Based on the percentage of animal origin, mAbs are divided into chimeric, murine, humanized, and fully human. This review covers the history and m Read More

Objective Shear flow is a mechanical signal regulating the function of Endothelial Cells (ECs). The present study aimed to investigate the effects of different matrices on cell binding, Nitric Oxide (NO) production, protein S-nitrosylation, expression of adhesion proteins, ROS generation, and cell viability in ECs under shear flow. Methods The ECs growing on glass slides separately coated with poly-L-lysine (p-Lys), collagen (Colla), fi Read More

Background Parkinson's disease (PD) and its associated symptoms are closely associated with the self-assembly of α-Synuclein (α-Syn). Squalamine is a naturally occurring chemical substance with established antiviral and anticancer properties, and its profound impact on the α-Syn aggregation both in vivo and in vitro is well studied. Examining its interaction with lipid vesicles, which are known to encourage nucleation, can signify Read More

Objective Helicobacter pylori, as a carcinogen, has been related to the development of gastric cancer, particularly in developing countries. The main challenge with therapy is the recurrence of antibiotic-resistant bacteria, and vaccination is still a problem. Therefore, the objective of the current study was to rationally design a multi-epitope vaccine using two immunogenic proteins found in H. pylori. Methods Promising epi Read More

Objectives Drug resistance reduces the antitumor efficacy of chemotherapy. Therefore, it is important to know how to reverse drug resistance. In this work, we investigated drug resistance reversal by StemRegenin-1(SR-1) in MCF-7/ADR cells and the mechanism by which it exerts its drug resistance effect. Methods MTT test and protein blot were employed as the two main in vitro cell tests. The cells were treated with SR-1 Read More