Coronaviruses - Current Issue

BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been shown to trigger autoimmunity, and the phenomenon leads to several chronic human diseases such as Type-1 diabetes, Crohn’s disease, vasculitis, Guillian-Barrė syndrome, etc. The mechanism underlying SARS-CoV-2-induced autoimmune response is unknown and is an active area of interest for the researchers.Obje Read More

Introduction‘Long COVID’ describes a wide range of symptoms lasting for at least four weeks after infection. Still, there are no therapies available right now that are intended to treat long-term COVID-19.Case PresentationHere, we reported a 36-year-old woman with 2 main issues: persistent symptoms for nine months after SARS-CoV-2 infection and selected symptoms after Sinopharm COVID-19 vaccination. In this case, after Read More

ObjectiveTo determine the association between changes in haematological parameters and mortality in patients hospitalized due to severe COVID-19 at a Peruvian reference hospital from April to December 2020.Materials and MethodsObservational, analytical, historical cohort study based on the review of clinical records of patients hospitalized due to severe COVID-19 from April to December 2020. We evaluated changes in co Read More

BackgroundEven after more than three years of emergence of coronavirus disease 2019 (COVID-19), it remains incurable, despite the use of emergency-approved vaccines. The impact of the emergency-approved vaccines against it is not highly certain. The entire world may face surge of new wave of the infection, and therefore, its reoccurrence cannot be denied. Causalities and economic losses may happen in the future. Read More

BackgroundThis study aimed to determine the differences in laboratory and clinical characteristics of pregnant and non-pregnant women with COVID-19 in Hamadan, the West of Iran.Material & MethodsThis cross-sectional study compared 135 pregnant with 135 non-pregnant women without underlying diseases and matched by age with COVID-19 from March 2020 to June 2021 in Hamadan, a western city in Iran. Their Read More

Background and ObjectiveIndia undertakes the largest COVID-19 vaccination drive in the world, which has undergone multiple changes since the beginning. We examined how these changes in strategy affect public perception, which is connected to the campaign’s success.Materials and MethodsA cross-sectional approach was undertaken, where non-health worker vaccine recipients at a COVID-19 vaccination centre in Ko Read More

BackgroundUnintentional behavioral changes brought on by the COVID-19 outbreak may have contributed to the increase in reported suicidal attempts. The coronavirus pandemic era has contributed to modifying existing domestic violence, mental health, conflict, and anxiety. Moreover, quarantine and self-isolation may have resulted in melancholy, suicidal thoughts, drug and alcohol misuse, and loneliness. Therefore, it i Read More

BackgroundCritically ill patients with COVID-19 have important risk factors for drug–drug interactions.ObjectiveThis study aimed to characterize and describe the profile and management of drug–drug interactions in critically ill patients affected by COVID-19 in a tertiary care hospital in Colombia.MethodsA descriptive retrospective cohort with an exploratory analytical component was used. The medical records of 191 pa Read More

COVID-19 causes a range of illnesses, from mild symptoms resembling the common cold to severe pulmonary damage leading to Acute Respiratory Distress Syndrome (ARDS). Researchers worldwide are actively searching for the most effective medications with minimal side effects for treating COVID-19. This review aimed to discuss the therapeutic potential of Curcumin (CUR) in managing COVID-19 infection in pati Read More

BackgroundThe Royal Thai College of Obstetricians and Gynaecologists (RTCOG) clinical practice guideline (CPG) does not recommend against elective Cesarean Section (CS) in case of prenatal maternal COVID-19 infections without obstetric indication. In Thailand, little is known about the mode of deliveries and perinatal outcomes in the mentioned group of patients. Therefore, this study aims to fill the gap in knowledge.Ob Read More

When light shines on an object, it sheds focus on the intrinsic characteristics of that material. Transmission of light or an electromagnetic (em) wave through a matter undergoes various physiochemical processes, like emission, absorption, and splitting of light into its constituent wavelengths. This interaction of em radiation with matter is widely used for the investigation of unknown and new target analytes in a sample, and the tec Read More

IntroductionTo shed light on the potential trajectories in the global mortality rate, the central question posed is the trajectory of global death rates in the years to come. This study was an effort to predict the trend of the global mortality rate following the COVID-19 pandemic until 2032 and, based on it, an attempt to contemplate potential solutions available for decision-making and planning.MethodsWe employed a time serie Read More

BackgroundThe novel coronavirus disease also known as COVID-19 was first detected in December 2019 in Wuhan, China and was caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its effect can still be seen in some parts of the world due to the lack of effective antiviral drugs and vaccines for treatment and controlling the pandemic. Chymotrypsin-like protease (3CLpro), also known as the main p Read More

BackgroundThe overcrowding conditions provide a favorable environment for viral transmission and increase the risk of respiratory infections among pilgrims. Hence, acute respiratory infections (ARIs) that can be transmitted through aerosols, droplets, and close contacts are a major public health concern during mass gathering (MG) events like Hajj.ObjectiveIn this study, we reported the prevalence of different respira Read More

BackgroundTwo independent sets of medical records, comprising 441 and 100 patients (50 smokers and 50 non-smokers), respectively, clinically diagnosed with COVID-19, suggested reduced death among smokers.MethodsMedical records from patients were examined to record the biochemical parameters available and to perform comparisons between smokers and non-smokers. Bioinformatics was used to predict Read More

Coronavirus Disease 2019 (COVID-19) is a pandemic disease caused by a novel virus, SARS-CoV-2. COVID-19-infected people have high chance of altered microbiota in various regions of the human body, such as gut, oral, and respiratory pathways. In one such case, gastrointestinal symptoms are mostly caused by the disturbances in gut microbiota. The gut microbiota shows magnificent changes in response to SARS-CoV-2 infe Read More

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) unleashed a global pneumonia pandemic, causing significant harm to both physical and mental health. It emphasized the urgency for specialized therapies and protective measures. Approaches, including immunotherapy, antiviral drugs, and lifestyle improvements, like diet and exercise, have shown promise in controlling viral spread before widespread vac Read More

BackgroundStudies suggest that cancer is a main complication regarding life expectancy and a foremost reason for death worldwide. For the treatment of COVID-19 infected 703,525,337 cases with 6,984,801 deaths worldwide up to February 21, 2024, well-designed pharmacotherapy management in different diseases, such as cancer, is respected. This investigation aims to review the current accessible medical treatm Read More