Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Cosmetic Science
  4. Volume 2, Issue 1
  5. Article
Volume 2, Issue 1
  • ISSN: 2666-7797
  • E-ISSN: 2666-7800

Abstract

Background

The process of wound healing is a complicated series of organized biochemical and cellular phenomena that restore the integrity of the skin and subcutaneous tissue. A drug molecule can be transported to the site of action through a variety of carriers, including niosomes or non-ionic surfactant vesicles. They can trap medications that are both hydrophilic and hydrophobic. It has been demonstrated that curcumin has strong analgesic, anti-inflammatory, and wound-healing qualities.

Methods

In the current study, an effort has been made to create a curcumin-loaded niosomal gel for efficient wound healing therapy. Utilizing non-ionic surfactants (Span 60, Span 20, Tween 20, and Tween 60) and cholesterol at various concentrations, a modified thin-film hydration process was used to create niosomal gels containing curcumin. Particle size, shape, entrapment effectiveness, deformability, and skin penetration were used to describe the vesicles. The 1% carbopol 940 gel was then made using the improved formulation. In wound-induced rats, the effectiveness of the wound healing was assessed.

Results

The manufactured niosomes were discovered to be homogeneous in size and spherical in shape. According to the IR spectrum study, the medication and formulation additives did not interact. It was discovered that the niosomal gel (S-3) loaded with curcumin was not irritating to the skin. According to studies on wound healing, curcumin-loaded niosomal gel exhibited the highest percentage of wound contraction. Following 21 days of niosomal gel treatment, the histopathological evaluation found a noticeable improvement in the skin's histological architecture. Curcumin-loaded niosomal gel was easily made using the thin film hydration process.

Conclusion

The results of this study demonstrate the potential of niosomal gel as a cutting-edge therapeutic strategy for wound healing.

© 2023 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cosci/10.2174/2666779702666230727124252
2023-10-04
2025-01-01

  • From This Site

    /content/journals/cosci/10.2174/2666779702666230727124252
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. KumarA. TakadaY. BoriekA. AggarwalB. Nuclear factor-?B: Its role in health and disease.J. Mol. Med.200482743444810.1007/s00109‑004‑0555‑y 15175863
     [Google Scholar]
  2. NamdeoA. JainN.K. Niosomes as drug carriers.Indian J. Pharm. Sci.199658241
     [Google Scholar]
  3. SaikiaA.P. RyakalaV.K. SharmaP. GoswamiP. BoraU. Ethnobotany of medicinal plants used by Assamese people for various skin ailments and cosmetics.J. Ethnopharmacol.2006106214915710.1016/j.jep.2005.11.033 16473486
     [Google Scholar]
  4. PalA. PalA.K. Radioprotection of turmeric extracts in bacterial system.Acta Biol. Hung.2005563-433334310.1556/ABiol.56.2005.3‑4.16 16196208
     [Google Scholar]
  5. ChanA.T. MansonJ.E. AlbertC.M. ChaeC.U. RexrodeK.M. CurhanG.C. RimmE.B. WillettW.C. FuchsC.S. Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events.Circulation2006113121578158710.1161/CIRCULATIONAHA.105.595793 16534006
     [Google Scholar]
  6. TawatsinA. WrattenS.D. ScottR.R. ThavaraU. TechadamrongsinY. Repellency of volatile oils from plants against three mosquito vectors.J. Vector Ecol.20012617682 11469188
     [Google Scholar]
  7. AbdelkaderH. AlaniA.W.G. AlanyR.G. Recent advances in non-ionic surfactant vesicles (niosomes): Self-assembly, fabrication, characterization, drug delivery applications and limitations.Drug Deliv.20142128710010.3109/10717544.2013.838077 24156390
     [Google Scholar]
  8. AbeY. HashimotoS. HorieT. Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages.Pharmacol. Res.1999391414710.1006/phrs.1998.0404 10051376
     [Google Scholar]
  9. AkbariJ. SaeediM. EnayatifardR. Morteza-SemnaniK. Hassan HashemiS.M. BabaeiA. RahimniaS.M. RostamkalaeiS.S. NokhodchiA. Curcumin Niosomes (curcusomes) as an alternative to conventional vehicles: A potential for efficient dermal delivery.J. Drug Deliv. Sci. Technol.20206010203510.1016/j.jddst.2020.102035
     [Google Scholar]
  10. AkbikD. GhadiriM. ChrzanowskiW. RohanizadehR. Curcumin as a wound healing agent.Life Sci.201411611710.1016/j.lfs.2014.08.016 25200875
     [Google Scholar]
  11. AlhatbabitaR. N iosomal drug delivery system-Promising drud carriers.Ali Nasir, Harikumar SL and KaurAmpreet.Niosomes: An excellent tool for drug delivery.IJRPC201222479486
     [Google Scholar]
  12. NasirA HarikumarSL AmanpreetK Niosomes: An excellent tool for drug delivery.Int. J. Res. Pharma. Chem.201222479487
     [Google Scholar]
  13. AlonsoJ.E. LeeJ. BurgessA.R. BrownerB.D. The management of complex orthopedic injuries.Surg. Clin. North Am.199676487990310.1016/S0039‑6109(05)70486‑2 8782479
     [Google Scholar]
  14. CollinsK.M.T. OnwuegbuzieA.J. JiaoQ.G. A mixed methods investigation of mixed methods sampling designs in social and health science research.J. Mixed Methods Res.20071326729410.1177/1558689807299526
     [Google Scholar]
  15. AntharjanmR.S. AnitaB. Curcumin as a treatment modality in recurrent aphthous stomatitis.Case Report. Kerala Dental Journal.2009324206208
     [Google Scholar]
  16. ManosroiA. KhanrinP. LohcharoenkalW. WernerR.G. GötzF. ManosroiW. ManosroiJ. Transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes.Int. J. Pharm.20103921-230431010.1016/j.ijpharm.2010.03.064 20381599
     [Google Scholar]
  17. AggarwalBB TakadaY ShishodiaS GutierrezAM OommenOV IchikawaH BabaY KumarA Nuclear transcription factor NF-kappa B: Role in biology and medicine.Indian J Exp Biol.2004424341353 15088683
     [Google Scholar]
  18. PrustyB.K. DasB.C. Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin.Int. J. Cancer2005113695196010.1002/ijc.20668 15514944
     [Google Scholar]
  19. LalB. KapoorA.K. AsthanaO.P. AgrawalP.K. PrasadR. KumarP. SrimalR.C. Efficacy of curcumin in the management of chronic anterior uveitis.Phytother. Res.199913431832210.1002/(SICI)1099‑1573(199906)13:4<318::AID‑PTR445>3.0.CO;2‑710404539
     [Google Scholar]
  20. BahramsoltaniR. FarzaeiM.H. RahimiR. Medicinal plants and their natural components as future drugs for the treatment of burn wounds: An integrative review.Arch. Dermatol. Res.2014306760161710.1007/s00403‑014‑1474‑6 24895176
     [Google Scholar]
  21. BaillieA.J. CoombsG.H. DolanT.F. LaurieJ. Non-ionic surfactant vesicles, niosomes, as a delivery system for the anti-leishmanial drug, sodium stibogluconate.J. Pharm. Pharmacol.201138750250510.1111/j.2042‑7158.1986.tb04623.x 2875149
     [Google Scholar]
  22. BalasubramanianK. Molecular orbital basis for yellow curry spice curcumin’s prevention of Alzheimer’s disease.J. Agric. Food Chem.200654103512352010.1021/jf0603533 19127718
     [Google Scholar]
  23. BankeyP. FiegelV. SinghR. KnightonD. CerraF. Hypoxia and endotoxin induce macrophage-mediated suppression of fibroblast proliferation.J. Trauma198929797298010.1097/00005373‑198907000‑00011 2664203
     [Google Scholar]
  24. BaumL. NgA. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer’s disease animal models.J. Alzheimers Dis.20046436737710.3233/JAD‑2004‑6403 15345806
     [Google Scholar]
  25. MaliA.M. GildaS.S. ParadkarA.R. BehalR. Evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: A clinical and microbiological study.J. Indian Soc. Periodontol.2011151353810.4103/0972‑124X.82264 21772719
     [Google Scholar]
  26. BischoffM. KinzlL. SchmelzA. The complicated wound.Unfallchirurg19991021079780410.1007/s001130050483 10525624
     [Google Scholar]
  27. BiswalS MurthyPN SahuJ SahooP AmirF Vesicles of non- ionic surfactants (niosomes) and drug delivery potential.International J. Pharmaceut. Sci. Nanotechnol.20081118
     [Google Scholar]
  28. Blazek-WelshA.I. RhodesD.G. SEM imaging predicts quality of niosomes from maltodextrin-based proniosomes.Pharm. Res.200118565666110.1023/A:1011037527889 11465422
     [Google Scholar]
  29. BoudraR. RamseyM.R. Understanding transcriptional networks regulating initiation of cutaneous wound healing.Yale J. Biol. Med.2020931161173 32226345
     [Google Scholar]
  30. LaoC.D. RuffinM.T.IV NormolleD. HeathD.D. MurrayS.I. BaileyJ.M. BoggsM.E. CrowellJ. RockC.L. BrennerD.E. Dose escalation of a curcuminoid formulation.BMC Complement. Altern. Med.2006611010.1186/1472‑6882‑6‑10 16545122
     [Google Scholar]
/content/journals/cosci/10.2174/2666779702666230727124252
Loading
Development and Evaluation of Curcumin-loaded Niosomal Gel for Wound Healing in Rats
Curr. Cosm. Sci. 2, E270723219218 (2023); https://doi.org/10.2174/2666779702666230727124252
/content/journals/cosci/10.2174/2666779702666230727124252
/content/journals/cosci/10.2174/2666779702666230727124252
Loading

Data & Media loading...


  • Article Type:     Research Article
Keyword(s): curcumin; histopathological; Niosomal gel; non-ionic; surfactant; wound healing

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test