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Volume 2, Issue 1
  • ISSN: 2666-7797
  • E-ISSN: 2666-7800

Abstract

Background

Recently, transferosomes have been discovered to have the potential for transdermal delivery. Curcumin is a bioactive molecule with anti-inflammatory and antioxidant properties, but it has low water solubility and poor skin absorption. The biological response to damage caused by diverse stimuli is known as the inflammatory process. Cyclodextrins are cyclic (-1, 4)-linked oligosaccharides of -D-glucopyranose with a hydrophilic outer surface and a hydrophobic center cavity.

Aims

The aim of the study was to develop a curcumin-loaded transferosomal gel to improve the wound healing process. The study has focused on advancing the area of traditional medicine in the field of pharmaceutics by using curcumin in the form of transferosomes to enhance wound healing.

Methods

Firstly, curcumin was used to synthesize the transferosomes. Secondly, the transferosomes were converted into a transferosomal gel as an alternative for wound healing. Characterization and investigation were carried out on female Swiss mice.

Results

Unpaired Student’s t-test was used to determine the statistical significance at < 0.5 using UV exposure schedules. All values have been expressed as mean ± SEM calculated by ANOVA with a significant difference among means at < 0.05.

Conclusion

The study has indicated curcumin to be successfully entrapped in transferosomes in order to formulate the gel with powerful wound healing properties.

© 2023 Bentham Science Publishers
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2023-09-18
2025-01-30

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/content/journals/cosci/10.2174/2666779702666230918094033
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Development and Evaluation of Curcumin-based Transferosomal Gel for Wound Healing
Curr. Cosm. Sci. 2, E180923221194 (2023); https://doi.org/10.2174/2666779702666230918094033
/content/journals/cosci/10.2174/2666779702666230918094033
/content/journals/cosci/10.2174/2666779702666230918094033
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  • Article Type:     Research Article
Keyword(s): carbopol; Curcumin-based; inflammatory process; transdermal delivery; transferosomal gel; wound healing

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