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Volume 2, Issue 1
  • ISSN: 2666-7797
  • E-ISSN: 2666-7800

Abstract

Background

Poor solubility of curcumin results in poor rate of absorption, rapid biotransformation as well as rapid rate of elimination. Due to this curcumin does not show better therapeutic effect through oral administration, to avoid poor rate of absorption, rapid biotransformation and topical drug delivery system plays a vital role.

Objective

The objective of the present work was the successful implementation of face-centered central composite design (FCCCD) to study various independent variables to develop an optimized formulation.

Methods

Carbopol 934 P and menthol were considered as independent variables and their impact was determined on dependent responses like drug content, viscosity, and percent drug release by developing topical gels using 32 central composite design. Thirteen curcumin loaded topical gels were prepared employing 32 CCD. Characterization of these formulations was done by drug content, viscosity, and percent drug release.

Results

The effect of independent variable, ., the concentration of Carbopol 934P and menthol was determined over the dependent variables by developing a response surface methodology. Optimized batch was investigated employing design expert software by overlay plot developed by statistical software with drug content, viscosity, and percent drug release 99.34%, 82.10 cps, and 65.576% respectively. Optimized data was evaluated by formulating four validation check batches. Promising results were observed by comparing the predicted values with experimental values, which proves the validity of the optimized data.

Conclusion

Therefore, it can be concluded that the application of face-centered central composite design is a useful statistical tool to get the optimized formulation with the least manpower, material, and money.

© 2023 Bentham Science Publishers
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/content/journals/cosci/10.2174/2666779702666230316093558
2023-05-04
2025-01-01

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/content/journals/cosci/10.2174/2666779702666230316093558
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Application of Face Centered Central Composite Design in Evolution of Optimized Drug Delivery System of Golden Nutraceutical with Frame Independent Variables
Curr. Cosm. Sci. 2, E160323214669 (2023); https://doi.org/10.2174/2666779702666230316093558
/content/journals/cosci/10.2174/2666779702666230316093558
/content/journals/cosci/10.2174/2666779702666230316093558
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  • Article Type:     Research Article
Keyword(s): Carbopol 934P; Central composite design; data validation; menthol; optimization; stability study; validation check

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