Current Organic Synthesis - Current Issue

Indolizidine alkaloids represent a diverse group of naturally occurring compounds which are derived from various sources and possess a wide range of pharmacological activities. Fused indolizidine alkaloids represent a distinct subset of these compounds, where additional rings are fused with the indolizidine core. When combined with the specific stereochemistry typically required for their biological activity, the fused ring structure Read More

The triazine moiety holds a special and very important position in the field of medicinal chemistry owing to its enormous biological and pharmacological potential. Over eras, triazine scaffolds have been investigated for synthesizing novel molecules that may be used for the treatment of different types of pathological conditions, such as infections, cancer, inflammation etc. A vast number of lead molecules ha Read More

Natural products, with their various sources from plants, marine organisms, and microorganisms, are considered a key source and inspiration for medicines and continue to be so. Indole alkaloids are a class of alkaloids and represent a large subunit of natural products. Indole alkaloids of biological importance are numerous and cover a wide range of pharmaceutical applications, including anticancer, antiviral, antimicrobia Read More

IntroductionAllelopathy related to a positive or negative impacts on one type of plant, by a chemical produced by another type of plant such as weeds, and different kinds of chemicals are hydroxamic acids, phenolics, and short-chain fatty acids. The potential allelopathic impacts of weeds is directly associated to the plan species used, as well as to the concentration of the aqueous extract available in the environment.Method Read More

BackgroundThiadiazoles exhibit a variety of biological activities, including antimicrobial, antiviral, antituberculosis, carbonic anhydrase inhibitor, antitrypanosomal agent, and anticonvulsant properties.MethodsThe new polymers are made in two distinct stages. The first stage is to prepare the starting material bis-(methyl-2-arylidenehydrazone-carbodithioates) via a condensation reaction between methyl-hydrazinecarbodithioat Read More

IntroductionThe reaction between 4-hydroxy-3,5-dimethoxyenzaldehyde and 2-ni-troaniline has been discovered, and the final product has been identified such as 2-6-dimethoxy-4-((2-nitrophenylimin)methyl)phenol (C1).Materials and MethodsX-ray diffraction examination performed on a single crystal provided conclusive evidence regarding the structure. Crystallography reveals that the two molecules A and B that were e Read More

BackgroundGiven the inadequacies of current chemotherapy, there is a need for more effective anticancer agents. Imidazole and thiazole compounds have demonstrated significant biological activity, making them promising candidates.Aims and ObjectivesThis study investigates the anticancer potential of imidazole and thiazole derivatives, focusing on liver cancer. The aim is to synthesize bis-imidazole-thiazole hybrid Read More

IntroductionHybrid inorganic/organic nanoparticles are used to make nanocomposites. These nanocomposites combine the different properties of the organic polymer and the inorganic nanoparticles, which improves the overall system properties.MethodsIn this research work, Mesoporous Silica Nanoparticle (MSN), amino-functionalized MSNs, and Covalent Organic Frameworks (COFs) were synthesized using a special appro Read More

IntroductionThis study includes synthesis, characterizations, antimicrobial, antioxidant, and docking molecular study of novel Bis-Azetidinone compounds that combined two units of β-lactam rings. In the present investigation, the aromatic aldehydes with primary amine were condensed to create Schiff's base, which was then reacted with chloroacetylchloride to produce bis-Azetidinone compounds.MethodsMelting points, FT Read More

BackgroundA direct synthesis of functionalized dimethyl fumarate derivatives of 2- (2-((E)-(2-oxoindolin-3-ylidene)methyl)-1H-benzo[d]imidazol-1-yl) is achieved via one-pot reaction involving 2-methyl-1H-benzo[d]imidazole and appropriate isatin in the presence of DMAD.MethodsConversely, this one-pot reaction furnished, upon conduction at 60 ℃, the 2-(2-((E)- (2-oxoindolin-3-ylidene)methyl)-1H-benzo[d]imidazol-1-yl) products. Read More