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Volume 22, Issue 3
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

Natural products, with their various sources from plants, marine organisms, and microorganisms, are considered a key source and inspiration for medicines and continue to be so. Indole alkaloids are a class of alkaloids and represent a large subunit of natural products. Indole alkaloids of biological importance are numerous and cover a wide range of pharmaceutical applications, including anticancer, antiviral, antimicrobial, anti-inflammatory, and antioxidant. Obtaining natural, biologically active indole compounds involves isolating them from their natural sources or preparing them synthetically. 3-Substituted indoles represent an emerging structural class of marine alkaloids based on their high degree of biological activity. 3-Acetyl indole is an important core used as a starting material for synthesizing many bioactive indole alkaloids. (5-Indole)oxazole alkaloids, β-carboline alkaloids, bis-indole alkaloids, chuangxinmycin, meridianine, and (±) indolemycin are the most important indole alkaloids that are prepared starting from 3-acety indole. The present review provides comprehensive information on the structures and the synthesis of bioactive indole alkaloids utilizing 3-acetyl indole and its derivatives as starting compounds. Additionally, it also spotlights the diverse biological activities of these compounds.

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2025-06-23

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/content/journals/cos/10.2174/0115701794325027240827043203
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3-Acetyl Indole in the Synthesis of Natural Bioactive Compounds
Curr. Org. Synth. 22, 328 (2025); https://doi.org/10.2174/0115701794325027240827043203
/content/journals/cos/10.2174/0115701794325027240827043203
/content/journals/cos/10.2174/0115701794325027240827043203
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  • Article Type:     Review Article
Keyword(s): 3-acetyl indole; biological activity; bis-indole; chuangxinmycin; indole alkaloids; indolmycin; meridianins; β-carboline

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