Current Organic Synthesis - Volume 9, Issue 6, 2012

This review deals with the state-of-the-art techniques in non-enzymatic nucleic acid condensation from monomers. In particular, the procedures called monomer self-condensation and template-directed monomer condensation are described, which have been developed to achieve efficient synthesis of long nucleic acid polymers or to sequence-specifically amplify nucleic acid polymers, respectively. Starting from molecular r Read More

In this article we discuss synthetic routes to organic conjugated oligomers and polymers bearing triple C-C bonds that have been recently developed in our laboratories, based on Pd-catalyzed Csp-Csp2 coupling reactions. Experimental protocols have been tuned to face synthetic challenges such as the presence in the main conjugated backbone of multifunctional substituents or uncommon conjugated units. The r Read More

Iriomoteolides are novel macrolides possessing either a unique 15-membered or a 20-membered macrocycle, and displaying exceedingly potent cytotoxicity with IC50 values of up to 2 ng/mL. Thus far, over a period of about four years, ten research groups worldwide have published their synthetic efforts resulting in four total syntheses of iriomoteolides and a few diastereomers thereof, and a number of fragment and mac Read More

Desymmetrization of prochiral compounds is one of the most efficient methods to obtain enantiomerically pure compounds (yield close to 100%); proof of this is its growing application over the last decade in the synthesis of key chiral intermediates used in the preparation of important biologically active compounds. Enzymes are highly specific, enantio- and regioselective catalysts that operate under relatively mild condi Read More

Vinyl and aryl sulfonates are ubiquitous building blocks in organic chemistry, frequently exploited in the total synthesis of natural and non-natural products, due to their ease of formation and to their high reactivity, especially in metal-catalyzed cross-coupling reactions. The present review thus aims at first describing the classical and current methods to prepare these valuable synthons, with an emphasis on reaction mechanism Read More

Aryl-fused 1,4-oxazepines and their corresponding oxo derivatives are structural components of a number of compounds exhibiting various biological activity. They were found to be useful as pharmaceuticals, for example as psychoneurotic, antihistaminic and analgesic agents. They are also known for relieving memory dysfunction such as that associated with reduced cholinergic function in Alzheimer's disease. Synthetic Read More

This brief review deals with the recent progress in the implimentation of thio-Claisen rearrangement in synthetic organic chemistry. Thio-Claisen rearrangement has been utilized for the synthesis of many heterocyclic moieties of biological significance. Stereoselectivity of the thio-Claisen rearrangement has also been discussed. This short report mainly covers the literature published during 2003 onwards.

Compared with conventional batch-wise process, one-pot synthesis is the “condensation” of two or more steps into one-pot operation and increasingly used in chemical process research and development in order to achieve the desired molecular complexity in ecologically and economically efficient way. One-pot synthesis can be achieved via multicomponent reaction (MCR), cascade reaction, tandem reaction, Read More

An efficient and regioselective one-pot direct synthesis of 4-vinyl-1,2,3-triazoles via cycloaddition of azides with propargyl alcohols and dehydration catalyzed by a CuCl/RuCl3.3H2O bimetallic catalysts in the presence of TFA (Trifluoroacetic acid) is developed.