Current Organic Synthesis - Volume 9, Issue 4, 2012

The Editorial Board wishes to dedicate this issue of “Current Organic Synthesis” to the Editor-in-Chief of the journal, Prof. Dr. Atta-ur- Rahman, FRS, on his 70th birthday. The Editorial Board acknowledges the tremendous achievements of Prof. Rahman in the fields of Organic Chemistry in general and on bioactive natural products in particular. Prof. Rahman's honors include: the first scientist from the Muslim world to have won the Read More

Without doubt, organic chemistry has made significant contributions in improving the qualities of our lives. However, there exists a demand for well-designed molecules of complex structures with additional requirements for low-cost and low-energy production of the materials, which stimulate us to consider innovative concepts in organic synthetic methods. In order to propose innovative methods for next-generation Read More

Modern organic synthesis requires easily obtainable chiral building blocks that show high chemical versatility for their application in diverse synthetic processes. The main purpose of this review is to present a survey of the scientific literature on levoglucosenone chemistry to provide an up-to-date on different stereoselective synthetic strategies for the construction of biologically important compounds, chiral inductors or Read More

Bicyclic oxazines are attractive compounds and valuable synthetic intermediates as they can be easily obtained by hetero Diels-Alder reactions between cyclic dienes and nitroso dienophiles. In particular, the more strained case (i.e. the [2.2.1]-cycloadduct) represents an interesting powerful combination of stability and reactivity as it can be transformed into highly densely functionalized cyclopentene derivatives by a variety o Read More

Selective catalytic reduction of halogenated nitroaromatic compounds is the most widely used method for the synthesis of halogenated anilines, important intermediates in the chemistry of pesticides, herbicides, drugs, pigments and dyes. This review reports progress made in the last decade in the field of hydrogenation of halogenated nitro arenes with the use of heterogeneous catalysts. The first sections of the review contai Read More

In 1881, Rainer Ludwig Claisen discovered a carbon-carbon bond-forming reaction between two esters or an ester and a carbonyl compound in the presence of a base. The reaction leads to β-keto esters or β-diketones respectively, and it was later named Claisen condensation, or classic Claisen condensation in the former case, and mixed (‘crossed’) Claisen condensation in the latter. The reaction now sits firmly in the repertoire Read More

β-Carboline represents the core unit of several alkaloids and bioactive agents. This review assimilates the reports pertaining to the synthesis and applications of 1-formyl-9H-β-carbolines for affording 1-substituted, C-1-N-9 and C-1-N-2 fused β-carbolines.

Over the past twenty years benzo- and naphtho[b]furan synthesis has been a widely studied topic, certainly due to the presence of this structural unit in many biologically active compounds. Most of the known methods of the synthesis of these heterocycles are based on an intramolecular cyclization of various open-chain precursors. There are four possible ways of the cyclization and they are based on a formation of appro Read More

Chromones are an important group of heterocyclic compounds due to their important functions in nature and their pharmacological applications. Many efficient syntheses of chromones have been reported through the years but the search for novel methods addressing to the preparation of this type of compounds still remains a relevant topic. Simple and efficient procedures using molecular iodine for the synthesis of these o Read More

A one-pot synthesis of 7-amino-4-oxo-3-(2-(2-thienyl)vinyl)-4,8-dihydro-[1,2,4]triazino[3,4-b][1,3,4]thiadiazine-8- carbonitrile (2) via the reaction of 4-amino-3-sulfanyl-6-[2-(2-thienyl)vinyl]-1,2,4-triazin-5(4H)-one (1) with bromomalononitrile is described. The formation of the new fused heterobicyclic and heterotricyclic nitrogen systems ([1,2,4]triazino[3,4-b][1,3,4]thiadiazin-7- yl)guanidine 3, pyrimido[4,5-e][1,2,4]triazino Read More