Current Organic Synthesis - Volume 9, Issue 1, 2012

Current Organic Synthesis now enters its ninth year since it started publication. It has grown over the years to be highly regarded among the community of synthetic organic chemists and today it has a very respectable Impact Factor of 3.95. This has been possible due to the constant support from the Associate Editors, Guest Editors and Editorial Board Members as well as the eminent authors who have chosen to publi Read More

Dr. Devdutt Chaturvedi obtained his Ph. D. degree in Medicinal Chemistry, from the Medicinal Chemistry Division of the Central Drug Research Institute (CSIR), Lucknow, India, in the year 2003. Thereafter, He worked as a Postdoctoral Fellow at the University of Georgia, USA. Later on, he has also worked as a Postdoctoral Fellow at the Institute of Organic Chemistry, University of Goettingen, Germany. He returned to India and Read More

Synthesis of organic compounds through a series of synthetic steps involves use of a variety of organic chemicals/solvents which are harmful either directly or indirectly. In recent years, water and ionic liquids have emerged as powerful green reaction media for various organic transformations and are frequently employed in organic synthesis affording excellent yields of the desired products. Several researchers in recent time h Read More

Cu-based catalysts represent a powerful tool for a variety of synthetic transformations, including arylation of nucleophiles, alkyne coupling, dipolar cycloadditions, Diels-Alder reactions, oxidations, condensations and enantioselective reactions. The use of water as reaction medium for these procedures is currently emerging as a very active research field. The present Review focuses on the more synthetically useful “on water Read More

In recent years water has emerged as a versatile solvent for the synthesis of a variety of organic compounds employing plethora of organic reactions. Water as a solvent is not only inexpensive and environmentally benign, but also exhibits new reactivity. The types of organic reactions in water are broad including pericyclic reactions, reactions of carbanion equivalents, reactions of carbocation equivalents, reactions of radi Read More

The Knoevenagel condensation is an important C-C bond forming reaction which has been extensively studied and also applied in industrial processes. Although it involves a dehydration step, the reaction can be successfully carried out in water to produce electron deficient alkenes and heterocyclic compounds such as coumarins. Here we review our works and recent articles concerning the Knoevengel condensation in Read More

Frequently, in spite of the use of a green reagent (the electron), the electrochemical methodologies are unable, owing to the presence of VOCs-supporting electrolytes solutions, to suggest very eco-friendly and competitive procedures of organic synthesis. In this paper, the possible utilization of room temperature ionic liquids, RTILs, as environmental-friendly solvents, instead of volatile and toxic solvents VOCs containing massi Read More

A novel class of chiral ammonium and imidazolium-based ionic liquids containing a chiral moiety and a free hydroxyl function has been designed and synthesized using (-)-ephedrine, isosorbide and isosmannide as naturally chiral sources. Some physical properties of these salts such as melting point, glass-transition temperature, thermal degradation, chemical stability and specific rotation have been characterized. These chiral i Read More

This review presents the recent applications of RTILs (Room Temperature Ionic Liquids) as reaction media in the main oxacyclic synthesis. Advantages and disadvantages of this green reaction media are described throughout the manuscript. Specifically allusion is made to the rates, mild conditions, co-catalyst, toxicity as well as the possibility of RTIL recycle, compared to the classical volatile organic compounds (VOC Read More

Due to their unique properties, ionic liquids (ILs) have become increasingly popular over the last few years in the field of green organic synthesis. This review provides an introduction to ionic liquids and aims specifically to describe diverse, recent applications of ILs in three main areas of organic synthesis: single-step chemical reactions in ILs, multistep reactions involving IL-phase synthesis, and multistep reactions in which Read More

This Review reports recent developments in the synthesis of benzo-fused heterocycles through Pd-catalyzed carbon-carbon and carbon-heteroatom bond forming reactions via direct C-H activation. Nitrogen-, oxygen- and sulfur-containing heterocyclic rings can be rapidly assembled starting from precursors with minimal preactivation. Compared to classical coupling reactions (i.e. Suzuki, Stille, Buchwald-Hartwig), the Read More

The polymer nanocomposites are composed of different nanometer units and organic polymer materials. In this review article, we have summarized different novel nanometer units which can be divided into inorganic materials and organic materials. For (inorganic materials)-polymer nanocomposites, the nanometer units include inorganic nanoparticle materials and inorganic nano-layered materials. The synthesis tech Read More

tert-Butyl esters are frequently employed in multi-step synthesis, especially with amino acid derivatives, and their importance is well established. On the contrary, tert-butyl ethers received less attention owing to the difficulties in their preparation and cleavage. Recently the tert-butyl ethers found employment also as fuel additives thus their synthesis became important and various protocols were developed. The present article will Read More