Current Organic Synthesis - Volume 14, Issue 8, 2017

Background: The incorporation of selenium (Se) atom onto organic scaffolds is a very promising approach to obtain more active and selective compounds against several types of cancer. During the last decade, a plethora of organoselenium compounds have been reported with very potent anticancer activity through diverse mechanisms of action, some of the most interesting being autophagy, angiogenesis, affectation of c Read More

Aim and Objective: Selenium (Se) compounds are often associated with good reactivity and selectivity due to specific modifications of thiol groups in peptides, proteins and enzymes. Among them, selenazolinium salts are of particular interest, as they react readily with their thiol targets. This study was undertaken to verify whether this reactivity translates into biological activity against a few selected organisms. Materials and Read More

Background: During the last decade, numerous research has indicated a promising perspective for selenophene and benzo[b]selenophene (BBS) as a promising scaffold for biologically active compounds. Selenophene is regarded as a bioisostere of benzene, hence numerous of selenophene derivatives have been synthesized to imitate the biological activities of benzene-containing analogues. Benzo[b]selenophene is regarded Read More

Background: As a chalcogen selenium has an interesting role in biology e.g. when it replaces sulfur in the amino acid cysteine, giving selenocysteine, which has an essential role in mammalian redox metabolism, being an essential part of the active site of mammalian glutathione peroxidase enzymes. Like other chalcogens selenium has several formal oxidation states and selenium compounds can interact with the Read More

Background: Sulfur-containing compounds are widespread among natural products and bioactive substances, and also useful ligands in asymmetric catalysis. Objectives: In this context, different methods for the preparation of oxazolidine- and oxazoline-2-thiones and their more recent applications are reviewed. Conclusions: In this survey, novel rearrangements and new reactions have also been summarized since 2007 until 2016.

Background: Since its discovery on the 1930 decade, phthalocyanines have occupied a prominent place in the textile and dye industries due to their thermal stability, low solubility and reactivity. However, over the last three decades, many different applications have been found for phthalocyanine derivatives including medicine, materials science, catalysis and energy fields. In this review, we discuss about the phthal Read More

Background: Tin-promoted allylation of carbonyl or imino groups is one of the most convenient and efficient methods for synthesis of homoallylic compounds, which are versatile building blocks in the preparation of many biologically active molecules and natural products. Objective: This review provides an insight into one-pot allylation reactions for the synthesis of different homoallylic compounds promoted by tin powder. Read More

Aim and Objective: Carbazoles and pyrrolidines derivatives exhibit a broad spectrum of biological and pharmacological properties, which exist in numerous drugs. Due to the high significance of these two classes of moieties in drug discovery, the synthesis of the compounds containing both of these two moieties are highly desirable. Method: A metal- and catalyst-free three-component decarboxylative coupling reaction of prolin Read More

Aim and Objective: We explore the role of IBX as an electrophilic agent towards the synthesis of flavones. The main objective was to work within the framework of green chemistry by using eco-friendly, less toxic, iodine-hypervalent reagent to carry out a facile conversion to flavones. Material and Methods: The use of 1equivalent of IBX under refluxing condition in DMSO was the best employed method for the synthesis of flavones. Read More

Aim and Objective: The carboxylation of organoboronic esters with CO2 is an attractive way of preparing the functionalized carboxylic acid derivatives. For the silver-catalyzed carboxylation of arylboronic esters with CO2, sensibility of catalytic system to CO2 pressure resulted in a high CO2 pressure required in the reaction. This work focuses on solving this problem and promoting this transformation under atmospheric Read More

Aim and Objective: In the chemical literature, there is very little data about copper catalysed synthesis of diaryl sulfides in water. In this work we present a novel highly selective Cu-catalysed “on-water” method of the synthesis of symmetrical and unsymmetrical sulfides from aryl iodides and 2-mercaptobenzoxazole as a novel sulfur transfer agent. Material and Method: 2-Mercaptobenzoxazole was presented as a novel sulfur Read More

AIM and Objective: The present work outlines the synthesis of pyrazoles and pyrazolo[1,5- a]pyrimidines from the reaction of 2-aryl-3-oxopropanenitrile with hydrazine monohydrate under different conditions. Reactions of 2-aryl-3-oxopropanenitrile with 2,4-pentanedione or ethyl acetoacetate furnished a mixture of highly functionalized pyridones and enamines through two different mechanistic pathways under va Read More