Current Organic Synthesis - Volume 14, Issue 1, 2017

This review imparts a survey on the synthesis and reactions of ethylidenethiosemicarbazides as well as their biological activities during the period from 2005 to 2015. The synthetic utilities of ethylidenethiosemicarbazides, as building blocks, for the synthesis of various heterocyclic compounds such as azoles, azines, and fused ring systems, have been demonstrated.

Tetraketones have attracted much attention because of their biological activities and molecular structure characteristics. Tetraketones are important precursors extensively used in the synthesis of acridinediones, as laser dyes and for the synthesis of various heterocyclic compounds. Tetraketones show significant lipoxygenase inhibitor activity and strong anti-oxidant potential. Also tetraketones are interesting due to th Read More

Benzimidazole and its derivatives are regarded as an important heterocyclic motif that exhibits a wide range of pharmaceutical applications including anticancers, antihypertensives, antivirals, antifungals, anti-HIVs, anti-convulsants, and anti-diabetics. In view of their wide ranging activities, the synthesis of benzimidazoles and its derivatives remain a primary focus for synthetic chemistry communities. Till date num Read More

Nowadays, the stereoselective synthesis of naturally occurring compounds showing biological activity has attracted much attention and stirred up the interest of organic synthetic chemists. Apparently, the multi-step total synthesis of such complex molecules bearing several stereogenic centers demands the development of the efficient and operational strategies for the induction of chirality in a certain step (steps). Among the m Read More

Background: Pyridazinone derivatives is considered a privileged structure that is currently experiencing a renewed interest in medicinal chemistry. Within this paper we studied the synthesis, structure and stereochemical aspects of some new Z-sinclinal/E-anticlinal acetylhydrazines isomers derived from pyridazin-3(2H)- ones. Methods: The synthesis of the desired pyridazinones with acetylhydrazine skeleton have been done Read More

Background: Hybrid systems based on steroids currently are drawing considerable attention in the area of drug development. In our recent work, we reported a Microwave (MW) irradiated Ugi-4 component reaction (Ugi-4CR) in synthesizing a number of steroid-amino acid conjugates based on seco-steroid hydroxyacids (A,B & D ring cleavage) in an expedited way giving very high yield of hybrid products. Considering the importa Read More

Background: Heterocyclic molecules have been synthesized by a green & facile strategy. These molecules contain a 8-membered azocine ring. The structures have been determined by spectral analysis and single crystal X-ray analysis. These compounds have anticancer activity. Method: A mixture of ninhydrin and acetone/ethylmethylketone in acetic acid in molar ratio 1:1 were heated on water bath for 15 minutes. The rea Read More

Background: The pyrrole ring is widely spread and incorporated into the structures of many naturally occurring compounds e.g. heme, chlorophyll, vitamin B12 and the bile pigments. Pyrrolnitrin and pyoluteorin are naturally occurring pyrroles which have antibiotic activity, and the methyl ester of 4-methylpyrrole-2-carboxylic acid is an insect pheromone. Moreover, the highly successful cholesterol lowering drug Lipitor is a poly s Read More