Current Organic Synthesis - Volume 14, Issue 5, 2017

Aim and Objective: In this review, we summarize the current state of varied multicomponent/onepot protocols for synthesis of vital pyrazole derivatives under varied conditions, including in absence and presence of catalysts, solvent and solvent-free conditions, and using other techniques such as microwave irradiation and ultrasonication. In broad sense, this review covers the publications up to 2015. Material and Method: Read More

Background: Catalytic kinetic resolution continues to be one of the hottest research topics in the community of synthetic chemistry owing to the huge demand of optically pure substances. Besides enzyme and transition metal-catalyzed asymmetric transformations, last two decades have witnessed tremendous advances enabled by organocatalysis. In this context, N-heterocyclic carbene catalysis, which is featured by its u Read More

Background: In the past decades, the hydroboration reaction was serendipitously discovered which occurred by the facile addition of diborane to alkenes and alkynes. Hydroboration reactions produce organoboranes. The organoboranes have marked a new era in the field of organic chemistry because they are versatile chemical intermediates that are readily available to chemists. Objective: The review focuses on recent advan Read More

Background: Simplification and cost reduction of the selenophene derivatives synthesis is of intense interest due to their increasing applications in functional materials and pharmacology. Since there has been significant progress in the chemistry of organoselenium compounds in the past 30 years, a large diversity of synthetic methods are available to perform selenophene ring formation. Objective: In this minireview, we emp Read More

Background: Pyrazole derivatives have remained a much studied class of heterocyclic compounds with application in several scientific areas such as agrochemicals, pharmaceuticals and building blocks for more elaborated structures. The cyclocondensation of enones with hydrazine derivatives is one of the most valuable ways of synthesizing pyrazole derivatives. This method produces a racemic mixture of 4,5-dihydro- 1H-pyraz Read More

Background: Multimodal imaging is a tool that may allow visualization, by using a single multifunctional compound, of early stage tumors and pharmacokinetic processes, drug action mechanisms and tumor growth processes, taking advantage of the strengths of each modality. Closely related, the emergence of “noninvasive” in vivo imaging revealed several “tip of the spear” contrast agent based technologies, e.g. Posi Read More

Background: The reaction named for Pietro Biginelli was first reported in 1891. The method consists of the reaction of an aromatic aldehyde, urea and ethyl acetoacetate leading to dihydropyrimidinones. Currently, the scientific movement to develop economically viable green methods using compounds that are reusable, nonvolatile, easily obtained, etc., is growing. Objective: A synthetic method was developed for the prepar Read More

Background: Construction of biaryls containing polyoxygenated groups via the palladiumcatalyzed Suzuki-Miyaura cross-coupling reaction of aryl halides with organoboronic acids is a very interesting area of research. A number of functionalized polyoxygenated biphenyls have received considerable attention during the past decades, due to their presence as the structural motifs in natural products with diversified biologi Read More

Aim and Objective: A new approach to synthesis of isoindoles condensed with other heterocycles and revelation of their spatial structure for biochemistry purposes was the main objective of this research. Material and Method: Starting materials for the proposed method, 1-furyl substituted pyrrolo[1,2-a]pyrazines, pyrrolo[1,2-a][1,4]diazepines and their benzoannulated analogues - 4-furyl substituted pyrrolo[1,2-a] Read More

Aim and Objective: The enzymatic method are used for the direct resolution of racemic atenolol. The catalytic activities of nine commercially available lipases were firstly compared, then all enzymes were tested for the kinetic resolution of (R,S)-atenolol by enantioselective acetylation in different reaction mediums. Additionally, the effects of the acetylating agent and its concentration were also investigated. The most effe Read More