Current Organic Synthesis - Volume 13, Issue 6, 2016

Benzofuran derivatives are the scaffold of many natural products, many of which are biologically active and/or found to have high potential as pharmacological agents. Therefore, benzofuran derivatives are expected to be invaluable moieties as far as biology and pharmacology are concerned. In this review, we try to highlight the recent advances in the synthetic approaches to a wide variety of its derivatives in parti Read More

Propylene carbonate (PC) is a polar aprotic substance with very similar physicochemical characteristics to the organic solvents traditionally used for organic synthesis, such as acetonitrile and acetone. Therefore, PC is beginning to be used as a “green” sustainable alternative solvent for chemical transformations. PC is a low toxicity, non-corrosive colourless liquid with a high boiling point and low vapour pressure. It is biodegradable Read More

The Diels-Alder (DA) reaction has been applied to the total synthesis of natural products. It can get good yields because of high stereoselectivity and regioselectivity. Herein, the DA reaction catalyzed by Lewis acids was introduced, and some total syntheses of natural products from 2013 to 2015 using DA reaction were also illustrated and analyzed.

Organic semiconductors are significant as highly prospective materials of reasonable costs for use in a broad range of organic electronics, i.e., light-emitting instruments, FETs, as well as solar cells. Semiconductors built with organic materials maintain their processing ability as related to polymeric units while also retaining their optical characteristics, i.e., elevated absorption coefficients and field-effect mobility close to th Read More

The new ruthenium vinylidene catalysts with general formula [RuCl2(=C=CHR)(PCy3)2] (R= -p- C6H4CF3 (I), -p-C6H4F (II) and -C6H9 (III)) were used in the cross-metathesis degradation of natural rubber (NR) using essential oils, β-pinene and d-limonene as chain transfer agents (CTAs). The isolated isoprene oligomer products with molecular weight around Mn x 104 g/mol were obtained when the reactions were carried out a Read More

Novel palladium-catalyzed cascade reaction of 2-methylindoles with 2- iodobenzyl bromide in the system Pd(OAc)2 / Xantphos / t-BuOK / toluene leading to indole- fused tricyclo[7,3,1,02,7] trideca-2(7),3,5-triene ring system was presented. Palladium catalyzed reaction of 2-methylindoles with 6-bromo-5-bromomethylbenzo[1,3] dioxole leads to 3,3-bis(6-bromobenzo[1,3]dioxol-5-ylmethyl)-2-methyl-3H-indoles.

This contribution discloses a simple and efficient procedure using environmentally benign supported cobalt nanocatalyst for the synthesis of bis(indolyl)methanes under solventfree conditions. The supported cobalt nanocatalyst exhibited excellent activity and stability and it could be reused for at least ten times without any loss of activity, providing an efficient and stable catalytic system for the synthesis of a number Read More

An efficient, green and facile protocol for the synthesis of pyranopyrazole derivatives through the reaction of aromatic aldehydes, malononitrile, hydrazine hydrate and ethyl acetoacetate was developed using Ru loaded hydroxyapatite (Ru-CaHAp) as catalyst. The eco-friendly one-pot reactions in an ethanol-water mixture are fast (≈15 min) and occur at room temperature. The catalyst was fully characterized by variou Read More

A series of epoxyesters were lactonized by HClO4 to give corresponding -hydroxy-γ-lactones as a mixture of diastereoisomers: trans and cis. The mixtures of products were separated via column chromatography. The lactones synthesized were screened for anticancer activity against D17 and U2-OS cell lines. Only the trans isomer with naphthyl ring was found to exhibit significant activity against both cell lines.

New series of thiazoles and thiadiazines incorporated with pyrazole ring were synthesized via the reaction of 2-(1-(4-cyano-1,5-diphenyl-1H-pyrazol-3-yl)ethylidene) hydrazine-carbothioamide or 4-imino-7-methyl- 2,3-diphenyl-2H-pyrazolo[3,4-d]pyridazine-5(4H)-carbothiohydrazide with different reagents. The structures of all tautomeric forms of the newly synthesized compounds were confirmed on the basis of spectral data aide Read More