Current Organic Synthesis - Volume 13, Issue 3, 2016

The reactions of sulfur ylides with carbonyl, olefin or imine compounds named as the Corey- Chaykovsky, provide oxiranes, cyclopropane or aziridine, respectively. In this report, we try to introduce this important name reaction and highlight a comprehensive overview on the applications of this useful reaction in synthetic organic chemistry and total synthesis of natural products.

This review involves the chemistry and biochemistry of lapachol, β-lapachone and lawsone, examples of bioactive natural products that still being under biological evaluation and stimulated several research groups to prepare derivatives and analogues and test them against several anticancer, trypanocidal, antinflammatory, tuberculostatic, and antimalarial targets, as well as other parasitology targets related to important infect Read More

The article covers some of the important prior art on solar-mediated organic transformations. It additionally highlights recent initiatives from our laboratory toward use of concentrated solar radiation to drive thermochemical and photo-thermochemical organic reactions. Solar radiation (800-1000 W m-2) comprises a continuum of photons of various wavelengths – from ultraviolet (uv) to visible (vis) to infrared (IR) – covering a Read More

Indan-1,3-dione is a versatile building block in organic synthesis. This review focuses on the applications of indan-1,3-dione to generate a large variety of indeno fused heterocycles such as Indeno-pyridine, diindenopyridine, indenoquinoline and indeno-cyclopenta-pyridine, indenofuran, indeno-indoloquinones, indenopyran, indenopyrimidine, indenotriazin-5-one, Indenoimidazole, indenopyrazoles and many others. Many o Read More

This review reports the methods developed for the synthesis of functionalized 1,2,4-triazines bearing phosphorus-amides as donor-acceptor interactions. These methods depend on the phosphorylation or phosphoimination of side functional groups of 1,2,4-triazine to produce isolated or fused phosphorus heterocyclic systems in view of their biocidal properties.

A new class of compounds, namely furo-imidazo-[3.3.3]propellanes can be synthesized by reaction of (1,3-dioxo-2,3-dihydro-1H-inden-2-ylidene)propanedinitrile with N-substituted (2-picolinoyl-, thiophene-2- carbonyl)hydrazinecarbo-thioamides 1a-f. 2,5-Disubstituted-2,3,4-oxadiazoles were also separated from this reaction as a minor product. The structures of products have been confirmed by using IR, NMR, mass spe Read More

We have developed a simple, efficient and green method for the preparation of 2,4,5-triaryl imidazoles using propylene carbonate (PC) as an alternative solvent in the Radziszewski reaction, avoiding other organic solvents such as AcOH, MeOH, EtOH, DMSO and DMF. A wide range of 2,4,5-triaryl substituted imidazoles were synthesized. The nature of the substituents on the aromatic aldehyde had no significant effect on the Read More

Brønsted acid catalyzed azlactone ring opening by amino acids leading to the synthesis of dipeptides is presented. Eleven compounds were synthesized in good to excellent isolated yields. Catalyst loading revealed that 5.0 mol % of (+/-)-CSA as an organocatalyst, under room temperature for 24 h, was suitable to promote this transformation.

New thiazole and 1,3,4-thiadiazole derivatives were synthesized from the reaction of hydrazonoyl halides and each of 3-(4-fluorophenyl)-3,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-2(1H)-carbothioamide and (E)-3-[mercapto(phenylamino)methylene]-thiochroman-4-one, respectively. The structures of all the newly synthesized compounds were established by elemental and spectral analyses. All of the synt Read More

New series of substituted thiazole were prepared starting from thiosemicarbazone derivatives 1a,b by reacting with different reagents namely, hydrazonoyl chlorides, dimethyl acetylene dicarboxylate, phenacyl bromide, chloroacetone, and chloroacetic acid. The structures of the newly synthesized compounds were elucidated on the basis of elemental analyses and spectral data. Some representative examples of the ne Read More

A series of new 5-imino-4-thioxo-2-imidazolidinone derivatives 3 with various halogenated and alkylated aromatic substituents at N1 and N3 was synthesized. Imidazolidineiminothione derivatives 3 were prepared from the reaction of N-arylcyanothioformamide derivatives with aryl isocyanates. These compounds were used as key synthons for the preparation of wide variety of new substituted imidazole compounds. Read More

Interesting and unexpected results on the cyanation of prochiral aldehydes catalyzed by chiral copper complexes of R-(+)/(S)-(-) α-ethylphenyl amine (I/II) in anhydrous methanol are presented. The cyanation reaction with chiral copper complexes of R-(+)/S-(-) α-ethylphenyl amines, acetols in methanol perform to afford a series of chiral products such as amines and acetonitriles (compounds 4-6, 8, 10 and 11). The obtained Read More