Current Organic Synthesis - Volume 13, Issue 5, 2016

Hydroxamic acids attracted much attention due to their ability to coordinate a range of transition metal ions. Siderophores can be highlighted due to their role as iron carriers in biological systems. This chelation ability joined to their occurrence in living organisms lead to their possible use as drugs. One of the most important pharmacological properties is their ability to inhibit enzymes, activity that can give them properties su Read More

This review covers the recent advances in the synthesis of enantiomerically pure hydroxylamine’s employing nitrones as starting materials. Nucleophilic additions of organometallic reagents to nitrones are the most common way for introducing a hydroxyamino group into carbon skeletons with the concomitant formation of a new carbon-carbon bond. Addition of nucleophiles derived from enolates, cyanide or fluor Read More

The formation of C-C and C-X bonds is a fundamental process in synthesis. In recent years organocatalysis has become a powerful tool to achieve these steps in a highly stereoselective manner and the nitro-Michael reaction was frequently used. From the functionalization of simple aldehydes, ketones or dicarbonyl compounds to the synthesis of privileged heterocyclic structures often found present in naturally occurring bioacti Read More

This review is focused on the synthesis of isoxazolidines as the core of biologically active compounds having anti-cancer, antiviral, antibacterial and anti-inflammatory properties. The isoxazolidine ring, as mimetic of ribose, has been principally synthesized with high regio-, stereo- and enantioselectivity, applying the methodology of 1,3-dipolar cycloaddition, involving nitrones and alkenes as dipoles and dipolarophiles, re Read More

The substrate of the classical Claisen rearrangement is ether containing double bonds in α and β positions. Both double bonds can belong to the aromatic system. There are about half a dozen known rearrangements in which one or more carbon atoms of the starting allyl vinyl ether were replaced with hetero-atoms such as sulfur, nitrogen or phosphorus. Such processes can be considered versions of the Claisen rearrange Read More

Five new unsymmetrically substituted salts containing a benzimidazole backbone were synthesized in high yields and their structures were verified via spectroscopic and analytical methods such as HRMS, 1D and 2D NMR spectroscopy, FT-IR and elemental analysis. The catalytic properties of all the synthesized salts were tested in a homogeneous Suzuki-Miyaura cross-coupling reaction to get coupling products in high efficiencies Read More

Some acidic functionalized ionic liquids were evaluated for catalytic properties in synthetic reaction of peracetylated thiosemicarbazones having D-glucose moiety. For the first time, the ionic liquid, namely, 2-hydroxyethylammonium acetate proved to be an efficient, environment-friendly and easy catalyst for synthesis of these thiosemicarbazones in water as solvent under microwave irradiation, with high yields. The greener f Read More

The coumarin derivatives have the anabolic, antioxidant, hepatoprotective, anticoagulant, HIV-proteases’ inhibitory, CNS depressant, hypnotics, sedative, diuretic, analgesic and antitubercular activities. In the present study, the synthesis of some 4-methylcoumarin derivatives in appreciably good yields has been achieved by the photo-irradiation of th e 2-methyl-3-(prop-2-ynyloxy)-4H-chromen-4-ones with pyrex filtered UV-lig Read More