Full text loading...
- ISSN: 1570-1794
- E-ISSN: 1875-6271
-
β-Aryl--Hydroxy-γ-Lactones: Synthesis, Structural Analysis and Cytotoxic Activity
- Source: Current Organic Synthesis, Volume 13, Issue 6, Dec 2016, p. 901 - 906
-
- 01 Dec 2016
Abstract
A series of epoxyesters were lactonized by HClO4 to give corresponding -hydroxy-γ-lactones as a mixture of diastereoisomers: trans and cis. The mixtures of products were separated via column chromatography. The lactones synthesized were screened for anticancer activity against D17 and U2-OS cell lines. Only the trans isomer with naphthyl ring was found to exhibit significant activity against both cell lines.
© Bentham Science Publishers