Current Organic Synthesis - Volume 13, Issue 2, 2016

Tetrahydroquinoline (THQ) subunits are present in many natural products and biologically active agents, such as anti-viral, anti-biotic, and anti-tumour medications. The synthesis of THQs is described extensively in literature due to the search for a general, simple, efficient and low-cost preparation method. The retrosynthetic analysis for THQ synthesis has many strategies involving the formation of one or two C-C or C-N Read More

Organocatalysts are small organic molecules that accelerate a reaction when used in sub-stoichiometric amounts. Their utility in various synthetically useful transformations have increased enormously in the past decade. Representing a link between two major forms of catalysis: metal complex mediated catalysis and enzymatic catalysis, the term ‘organocatalysis’ establishes connectivity between synthetic and bi Read More

Pyridinium chlorochromate (PCC) is an important reagent in organic synthesis used primarily for the selective oxidation of alcohols to give carbonyl compounds. Although a variety of related compounds are known with similar reactivity, PCC offers exclusively the advantage of the selective oxidation of alcohols to aldehydes, whereas many other reagents were less selective. Disadvantages of using PCC are the tedious reacti Read More

Advances in the application of aluminum-based metal alloys in the hydrogenation as well as deuteration of a broad range of organic compounds are reviewed. The use of the Al-based alloys allows, and in fact favors, the reaction to be carried out in aqueous medium, which is a major step forward for reduction reactions given the recent need for environmentally benign reaction design. The Al content of the alloy, used as r Read More

A unified convergent strategy has been developed for the facile synthesis of a series of novel fused azines bearing a phenothiazine moiety based on the aza-Michael addition reaction of an enaminone derivative to a variety of different heterocyclic amines under microwave irradiation conditions. The results of this study revealed that new methods are required to allow for the simple and efficient analysis of the fused az Read More

A series of novel cyclohepta[1,2-d][1,2,4]triazolo[4,3-a]pyrimidines was prepared by reaction of 9- arylmethylene-cycloheptapyrimidine-2-thione with hydrazonoyl halides in dioxane in the presence of triethylamine. Also, a series of fused cycloheptapyrimidines was synthesized via reaction of 2,7-diarylmethylenecycloheptanone with heterocyclic amines. The products 14a-c of the latter reaction were used as starting materials Read More

A new aci-quinone compound, 4-(aci-nitro)-2-(methoxy)-5-(3-nitro-2-(nitrooxy)propyl)-cyclohexa-2,5- dienone (2), an analog to 4-(aci-nitro)-2-(carboxymethoxy)-5-(3-nitro-2-(nitrooxy)propyl)-cyclohexa-2,5-dienone (1), was successfully synthesized and fully characterized by spectroscopic methods. The reactions of 1 and 2 with various reagents such as hydroxylamine, acetic anhydride, semicarbazide and thiosemicarbazid Read More