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- Volume 12, Issue 6, 2015
Current Organic Synthesis - Volume 12, Issue 6, 2015
Volume 12, Issue 6, 2015
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Application of Bio-Based Solvents in Catalysis
Authors: Arlene G. Correa, Marcio W. Paixao and Ricardo S. SchwabEnvironmental concerns associated with synthetic organic chemistry have posed stringent and compelling demands for greener processes. The development of cost-efficient and environmentally benign catalytic systems has become one of the main subjects in modern chemistry. In many chemical processes, organic solvents are widely used and had been a cause of major environmental concern due to their hazards. A rec Read More
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Contributions on Kinetic Resolution by Lipases on the Development of Organic Synthesis in Brazil
Authors: Leandro H. Andrade, Bruno A. Sousa, Irlon M. Ferreira and Andre L. M. PortoIn recent decades the need for new chiral compounds with high enantiomeric excesses has been rapidly emerging. Among the various methods used to achieve chiral compounds, one can highlight the enzymatic kinetic resolution of racemic esters, alcohols and amines and as the most versatile enzymatic methodology used in organic routes. Enzymes are used in biocatalytic routes to obtain enriched and enantiomericall Read More
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Drug Likeness and Selective Functionalization of Quinoxalines
In recent years, the pharmacological potential of quinoxalines has received vast interest due to its many applications. This review centers on a critical overview of chemical diversity and physicochemical properties of bioactive quinoxaline libraries. In addition, recent strategies for obtaining structurally diverse quinoxalines using highly selective processes will be discussed.
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Novel Synthetic Compounds as Potential Anticryptococcal Agents
Cryptococcosis, an invasive fungal infection that affects both immunocompromised and immunocompetent individuals, has emerged as an important public health problem in Africa, Asia, and America. The limited number of antimycotic drugs available to treat this disease, their side effects and toxicity, and the emergence of resistant strains support the search for more effective and less toxic compounds. This review Read More
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Synthetic Strategies for the Preparation of Butenolides and Their Transformation into Other Derivatives
Authors: Luiz C. A. Barbosa, Robson R. Teixeira and Giovanni W. AmaranteButenolides, five membered α,β-unsaturated γ-lactones, are ubiquitous moieties present in the structures of many natural products and synthetic compounds endowed with a large array of biological activities. Butenolides with an γ-alkylidene moiety are termed as γ-alkylidenebutenolides. Because of their chemical structures as well as their biological activities, butenolides have attracted the attention of synthetic organic ch Read More
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Palladium-Catalyzed Oxyarylation, Azaarylation and α-Arylation Reactions in the Synthesis of Bioactive Isoflavonoid Analogues
Authors: Camilla D. Buarque, Jorge L. O. Domingos, Chaquip D. Netto and Paulo R. R. CostaIsoflavonoids constitute an important class of natural products, comprising great structural diversity. Known as phytoalexins and phytoestrogens, these compounds exhibit interesting biological activities. The corresponding carba-analogues, in which the oxygen atom at the B-ring is replaced by a methylene, are emerging as an attractive alternative for the preparation of new bioactive compounds. In this review, we report our re Read More
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Recent Advances in the Asymmetric Claisen Rearrangement Promoted by Chiral Organometallic Lewis Acids or Organic Brønsted-Lowry Acids
More LessThe Claisen rearrangement, an important C–C bond forming reaction, has been used enormously for many decades in the synthesis of important class of compounds. This review covers developments in this rearrangement since 2008, discusses important aspects about the asymmetric Claisen rearrangement catalyzed by chiral organometallic Lewis acids or organic Brønsted-Lowry acids.
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Importance of Organic Synthesis in the Development of Liquid Crystals
Authors: Hugo Gallardo and Eduard WestphalLiquid crystals are fascinating materials in many areas of applied science. They are widely known for their application in display technology and uses in other fields have also recently been identified, such as anisotropic networks, organic light-emitting diodes and photo- and semiconducting materials. Further applications in new areas continue to be developed, as well as effective solutions to problems associated with the limit Read More
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Copper-Catalyzed One-Pot Multicomponent Reactions: Synthesis of 4-Arylsulfenyl Pyrazoles
Authors: Daniela H. Oliveira, Diego Alves, Raquel G. Jacob and Mauricio C. D. F. XavierWe describe here a simple protocol for the synthesis of 4-(arylsulfenyl)-1H-pyrazoles by copper-catalyzed cyclocondensation and direct C–H bond sulfenylation reactions. The products were obtained in good yields by the reaction of a range of 1,3-diketones, arylhydrazines and arylthiols, using catalytic amount of CuI. This One-Pot Multicomponent protocol is an efficient method to synthesize new compounds with potential applic Read More
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The Morita-Baylis-Hillman Reaction: Advances and Contributions from Brazilian Chemistry
More LessThe Morita-Baylis-Hillman reaction is an organocatalyzed chemical transformation that allows access to small poly-functionalized molecules and has considerable synthetic potential and promising biological profiles. In this review, we report the efforts made by Brazilian research groups in recent years on the development of Morita-Baylis-Hillman chemistry. The review covers these contributions, with a focus on mechanistic studies Read More
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Volumes & issues
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Volume 22 (2025)
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Volume 21 (2024)
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Volume 20 (2023)
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Volume 19 (2022)
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Volume 18 (2021)
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Volume 17 (2020)
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Volume 16 (2019)
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Volume 15 (2018)
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Volume 14 (2017)
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Volume 13 (2016)
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Volume 12 (2015)
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Volume 11 (2014)
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Volume 10 (2013)
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Volume 9 (2012)
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Volume 8 (2011)
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Volume 7 (2010)
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Volume 6 (2009)
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Volume 5 (2008)
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Volume 4 (2007)
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Volume 3 (2006)
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Volume 2 (2005)
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Volume 1 (2004)
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