Current Organic Synthesis - Volume 12, Issue 3, 2015

Fused heterocycles constitute the largest diversity of heterocyclic compounds of chemical and biomedical significance. They widely exist in numerous natural products. They are also among the most frequently encountered scaffolds in numerous drugs and pharmaceutically relevant substances. This review highlights some remarkable achievements made in the synthesis and chemistry of pyridotriazolopyrimidines tha Read More

Other than their valuable use as starting materials and intermediates in the synthesis of drugs and other important organic compounds, pyridinyl alcohols are largely used as hemilabile chiral chelating ligands in the development of homogeneous transition metal catalysts. The pyridinyl alcohols covered in this review are divided into four types based on the position of the alcohol group and number of the pyridine ring, na Read More

Polysaccharide is a kind of biological material, which has good biocompatibility, non-toxicity, and nonimmunogenicity. So, the polysaccharide has been widely applied in drug delivery system. The chemical modifications of chitosan and hyaluronic acid as drug carriers were summarized herein.

The conversion of alcohol to alkyl halide in the presence of triphenylphosphine and carbon tetrahalide, which is commonly known as the Appel reaction, is an important route for halogenations under mild and neutral conditions. During the past twenty years, the Appel reaction has experienced a considerable evolution. Several convenient reagents have been developed and applied as electrophilic halogen sources d Read More

This review focuses on the recent applications of Burgess reagent in the synthesis of organic compounds, with the emphasis, on the total synthesis of natural occurring products.

A series of new biscoumarins have been synthesized in excellent yields and short reaction times by nucleophilic addition reaction of aldehydes and two equivalents of 4-hydroxycoumarin. The reaction was efficiently promoted by 0.05 g nano Fe3O4 and the catalyst could be recovered easily after the reactions and reused without evident loss of reactivity. All the compounds exhibited strong antibacterial activity towards two Gr Read More

Application of silica nanopowder (15 nm) supported by potassium hydrogen sulphate has been demonstrated to be an effective recyclable catalyst system for the opening of terminal epoxide ring using alcohol and/or amine nucleophiles regioselectively at the terminal position in 3 hours at external temperature 70 °C. The terminal insertion of nucleophile has also been observed with potassium bisulphate supported on silica Read More

A new 6-spiro (testosterone-3′-yl)-hexahydro-3-thioxo-1,2,3-triazin-5-ones (4a and 4b) have been synthesized by the condensation of testosterone and17-methyltestosterone(1a and 1b respectively) with thiosemicabazide. The first analogous 5 were obtained by oxidation while the second analogous 6-spiro (testosterone-3′-yl)-3-(4′-fluorophenyl)amino-1,2,3-triazin-5-ones (6) obtained by reaction of 4 with 4-fluoroaniline. Th Read More