Current Organic Synthesis - Volume 12, Issue 4, 2015

One of the actual goals in the field of macrocyclic research is to provide accessible chemically robust compounds with absorption in the NIR spectral region. This requirement can be fulfilled in the case of tetrapyrrolic derivatives such as porphyrins, phthalocyanines etc with extended system of electronic conjugation. In this short review, we focus on the available approaches for the synthesis of cycl[3.2.2]azine-1,2-dica Read More

To generate series of useful compounds from hydrocarbons, various reactions which are able to satisfy these requests such as addition reactions to carbon/carbon multiple bonds, nucleophilic ring-opening reactions, carbonyl chemistry of the “non-aldol” type, cycloaddition reactions and so on have been studied in-depth. And in general, the preactivation of coupling synthons is always required for such cross-coupling methodolo Read More

This review primarily focuses on the publications within the last 25 years (i.e. from 1990 to 2014) related to the advances in the synthesis and reactions of annulated 3-amino-4-iminopyrimidines. The literature results covered in this review demonstrate that the studied reactions are chemo-selective.

The bisabolane sesquiterpenes, which have been isolated from different natural sources, are an important class of compounds. They exhibit a wide range of biological activities. They have a benzylic stereogenic centre, carrying a methyl group at this position. Among the major group of bisabolane sesquiterpenoids, curcumene is an aromatic compound, which has been widely studied. (S)-(+)-curcumene is a constituent o Read More

The development of smart supramolecular gelators whose self-assembly propensity can be controlled by physical processes such as sonication is highly interesting. Upon sonication, the designer gelators form in situ gel in organic solvents or water with diverse folding and assembly. These sonication responsive supramolecular gels have various applications such as switches, extra cellular matrix for tissue engineering, adva Read More

Reported here are two novel cationic domino reactions of 2-arylmethylideneindoxyls leading to the formation of highly substituted dispiropseudoindoxyls or 9-oxo-pyrrolo[1,2-α]indoles. The outcome of the reactions can be controlled by the appropriate choice of an acid or the application of an external nucleophile. The dispirocyclodimers are formed in single diastereomeric forms with three stereogenic centers, Read More

Superparamagnetic nanoparticle-supported imidazole (Im@MNPs) was prepared and used as magnetically separable catalyst for Knoevenagel condensation of aromatic aldehydes with active methylene compounds. 3.0 mol% of Im@MNPs with water as solvent was investigated as the optimal catalytic system. The active methylene compounds involved malononitrile, ethyl 2-cyanoacetate, 2-(1H-benzo[d]imidazol-2-yl)ac Read More

Starting from 4-ethylguajacol in only 3–4 steps the new photolabile protecting group (PPG) precursors AMNPPol and AMNPPOCOCl can be obtained, which are suitable for the protection of the N- and the C-terminus of amino acids and peptides. The incorporated allyl functionality allows subsequent ring closing reactions with other unsaturations in the peptide. These protecting groups can be removed faster than the com Read More

Diversity oriented, efficient and environmentally benign synthetic protocol has been presented for the synthesis of spiroquinazolinones. The hybrid drug-like small molecules incorporating medicinally privileged heterocyclic systems have been synthesized by tandem reaction of 3-aminocrotonnitrile, phenyl hydrazine/ hydrazine hydrate, isatoic anhydride and isatin using deep eutectic solvent as efficient catalyst and Read More