Current Organic Synthesis - Volume 12, Issue 1, 2015

Hydroxycarbazoles are versatile and widely used starting materials capable of react with a variety of synthons. This review provides a source which pulls together the known one-pot and multistep synthesis of carbazole heterocycles such as, furocarbazoles, indolocarbazoles, indoloisoflavones, indoloxanthanes, isochromenocarbazolones, pyranocarbazoles, pyridocarbazoles using hydroxycarbazoles as precursors.

The multicomponent reaction (MCR) is an important research field in the organic synthetic methodology. In 1956, Professor Friedrich Asinger reported a method for synthesizing thiazoline scaffold, in which a ketone was treated by sulfur and ammonia in one-pot operation. In 1998, Professor Katrin Groebke, Hugues Bienayme, and Christopher Blackburn reported a method for preparing imidazo[1,2-a]pyridine, in whi Read More

The synthesis of a new non-cross-linked polystyrene supported cyclosulfamide chiral auxiliary is described. Asymmetric aldol reactions using this auxiliary proceeded with good yields and excellent stereoselectivities, which were comparable with those observed by using non-supported cyclosulfamide chiral auxiliary. Furthermore, recovery and recycling of this polymer supported chiral auxiliary have been successfully ac Read More

An efficient methodology for the synthesis of alcohols in high yields with the selective deprotection of methoxy methyl (MOM) ethers using Zinc(II) trifluoro methane sulfonate (Zn(OTf)2) in isopropanol as a solvent under reflux conditions was reported.

A new family of bipolar hosts TPA-DAF, TPA-(DAF)2 and TPA-(DAF)3 based on triphenylamine and 4,5- diazafluorene moiety were synthesized through Friedel-Crafts reaction, and all of the three prepared hosts showed excellent thermal stability and exhibited blue fluorescence in solution.

An efficient, three component synthesis of novel class of mono, bis and trisdihydropyridines which are fused with pyrazole rings from reaction between pyrazolecarbaldehyde, dimedone and ammonium acetate was described. In this research, mono, bis and trisdihydropyridines were synthesized in the presence of a catalytic amount of recyclable catalyst, nano particle Fe3O4.

A novel and flexible synthetic approach to enureas is described. This convenient method has been developed for the Pd-catalyzed C-N coupling reaction of alkenyl nonaflates with a variety of ureas. A ferrocene based phosphine ligand, Joshiphos appeared noticeable as the most dynamic catalyst and K3PO4 in t-BuOH was established to be the most favorable base-solvent combination for the reaction. This catalyst system Read More

The domino Knoevenagel/Diels-Alder condensation is a highly efficient strategy for the preparation of heterocyclic compounds. In order to study this reaction with an imine catalyst, a three-component reaction involving aromatic aldehydes, benzylideneacetone and meldrum acid catalyzed by a series of new organocyclic amino acid catalysts was developed. This simple experiment and environmentally friendly method is benefi Read More

A direct and efficient approach for the synthesis of new series of pyrido[3,4-c][1,5]benzothiazepine, pyrido[4,3-d]triazolo[1',5'-a]pyrimidines, pyrido[4,3-d]tetrazolo [1',5'-a]pyrimidine and pyrido[4,3-4',5']pyrimido[1',2'- a]benzimidazoles has been developed via condensation of o-aminothiophenol and heterocyclic amines each with 1-ethyl- 4-piperidinone and the appropriate aldehyde. The reactions were performe Read More

A diastereoselective synthesis of functionalised tetrahydroquinolines was performed using a one-pot imino Diels-Alder cycloaddition reaction of anilines, benzaldehydes and isoeugenol at room temperature using propylene carbonate as an environmentally friendly solvent and molecular iodine as an efficient catalyst. This new protocol has the advantages of higher yields, mild conditions, simple methodology, a short reacti Read More