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Volume 29, Issue 8
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

Dihydrocoumarins play pivotal roles as essential components in biologically active molecules, drugs, and flavor and fragrance compounds. In particular, chiral 3,4-dihydrocoumarins exist in natural products, exhibit less toxicity, and possess structural diversity and stability. Consequently, the asymmetric synthesis of these scaffolds has garnered considerable attention within the chemistry community. Recent advancements have witnessed their synthesis achieved through both metal and organocatalyzed approaches. In this review, we analyze and discuss the advancements made in chiral-organocatalyzed asymmetric synthesis of dihydrocoumarins since 2015. This review is structured according to the type of catalyst employed in the transformation, providing a comprehensive examination of the recent developments in this field.

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2024-09-23
2025-05-04

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Organocatalytic Stereoselective Synthesis of Dihydrocoumarins
Current Organic Chemistry 29, 599 (2025); https://doi.org/10.2174/0113852728331488240828074740
/content/journals/coc/10.2174/0113852728331488240828074740
/content/journals/coc/10.2174/0113852728331488240828074740
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  • Article Type:     Review Article
Keyword(s): asymmetric synthesis; chiral phosphoric acid; Dihydrocoumarin; squaramide catalyst; stereoselectivity; thiourea

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